Nichols is the author of The Genius of Impeachment (The New Press); a critically acclaimed analysis of the Florida recount fight of 2000, Jews for Buchanan (The New Press); and a best-selling biography of Vice President Dick Cheney, Dick: The Man Who is President (The New Press), which has recently been published in French and Arabic. He edited Against the Beast: A Documentary History of American Opposition to Empire (Nation Books), of which historian Howard Zinn said: "At exactly the time when we need it most, John Nichols gives us a special gift--a collection of writings, speeches, poems, and songs from throughout American history--that reminds us that our revulsion to war and empire has a long and noble tradition in this country."

With Robert W. McChesney, Nichols has co-authored the books It's the Media, Stupid! (Seven Stories), Our Media, Not Theirs (Seven Stories), Tragedy and Farce: How the American Media Sell Wars, Spin Elections, and Destroy Democracy (The New Press), The Death and Life of American Journalism (Nation Books) and, most recently, Uprising: How Wisconsin Renewed the Politics of Protest, from Madison to Wall Street (Nation Books). McChesney and Nichols are the co-founders of Free Press, the nation's media-reform network, which organized the 2003 and 2005 National Conferences on Media Reform.

Of Nichols, author Gore Vidal says: "Of all the giant slayers now afoot in the great American desert, John Nichols’s sword is the sharpest."