It was recently suggested that an increase in noncommunicable diseases (NCDs) among children over the last half century may be attributed to exposure to synthetic chemicals and plastics and that this indicates the need for precautionary regulatory reforms (Wirth et al. 2025). Although protecting children’s health is commendable, this is a complex issue. Wirth et al. (2025) conflate correlation with causation, focus only on hazard identification, overlook substantial progress in regulatory frameworks and scientific understanding, and raise unnecessary alarm (Freeman and Spiegelhalter 2018). We contend that public health, including that of children, can best be protected by evidence-based approaches without the need to forego the necessary benefits that manufactured chemicals bring to modern society. In this article, we identify key gaps in linking NCDs with chemical exposure, with an emphasis on how current regulatory systems support their safety in use.