2015-08-20

In 2015, a huge bibliography and “good footnotes” still set PainScience apart.1My footnotes contain either extra commentary and whimsical asides, or citations to science and other sources, like this:

Woolf CJ. Central sensitization: Implications for the diagnosis and treatment of pain. Pain. 2010 Oct;152(2 Suppl):S2–15. PubMed #20961685. PainSci #54851. And I’ve just upgraded them.

Bibliographic data does not play nicely with modern publishing technology. There’s lots of software for wrangling references on your PC, but it’s still almost impossible to integrate them (efficiently) into blogs and websites. It still has to mostly be done “manually.”

I started investing in a good system to solve this problem in 2005, but it had to be custom job — pure original programming. The result has been a quietly awesome and esoteric boon to my publishing business ever since. My referencing is noticed by many visitors to the site, because there’s nothing else quite like it anywhere else online. Footnotes in long-form online writing are sparse and spartan.

But it was time for some improvements. Got stay ahead of the curve. This is about what I did, and some behind-the-scenes details.

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A craaaazy amount of work

Pulling this off tooks weeks of work spread out over months, but almost everything is better:

More information! I revised the summaries of over 400 most-cited papers (out of about 2500). Imagine going back and editing a couple year’s worth of regular science blogging. 100 of the best examples are linked below.

Faster, nicer! Those revised summaries load up about 10× faster, and they’re easier on the eyes.

Organized! The index to the entire bibliography is also much faster and it sucks much less.

More formal! I converted my referencing format to the “Vancouver system,” the standard used by most medical journals.

That last one was particularly challenging and interesting. Why “Vancouver”? My town?

The old way: dumbed-down references

PainScience isn’t a medical journal, and all of my readers in the early days were “just folks,” so why put on airs? I made my references simple: just the essential information, uncluttered with stuff like 82(123):987-93. (But always with a link to those details, so that a reference could be checked up on — that’s very important, even for just folks.)

It was idealistic and modern. I was declaring what I thought web referencing should be like.

Plus, it is really hard to mass produce the formatting of detailed bibliographic data. So I didn’t.

The new way: more formal = more serious

It’s hard to get taken seriously when you don’t act serious. Regular readers aren’t bothered by formality and detail, not in a footnote, but special visitors — proper experts — definitely notice if I don’t speak their referencing language. Those influential readers won’t know that I’m being clever and innovative and democratic.

“They’ll just think you don’t know how to reference properly,” my wife said about five years ago.

“And they’ll be right,” I said. “I don’t really have a clue. It looks nasty.”

“Time to learn, maybe.”

“Maybe. I should get started on the procrastinating, at least.”

And then I started getting email from people who agreed with my wife. My writing was getting noticed. My website was getting big. Getting referencing right mattered more with each passing year.

[better citations needed]

The Vancouver system of referencing

About six months ago I Googled “standard medical journal referencing format.” After all these years, I wasn’t even sure if there was such a standard. That’s when I discovered “the Vancouver system,” and it kicked off months of work. I had to re-tool the footnote factory, and re-train all the bibliography gnomes. (Weirdly, I felt much more comfortable diving into this Sysyphean chore simply because the new standard was named after where I lived.)

So, why Vancouver?

In 1978, editors of medical journals from around the world met in the city of Vancouver, probably close to where I live, and thrashed out the unbelievably numerous details. It was so difficult and tedious that they named the standard after the city they were trapped in. Their work is still the standard today, and it is heavily documented.

I encourage you to click that link and scroll for a while and behold my nightmare. The Vancouver system is about as user-friendly as a swarm of cranky wasps.

The devil is in the details

All my references are generated from a bibliographic database in the fairly exotic BibTeX data format. Every footnote is lovingly crafted by software — essential for mass production. I had to reprogram that software to speak “Vancouver style.”

In programming, an “edge case” is something that requires special handling. You might have 50 lines of code that do something with 95% of your data, and then another 50 lines of code just to cope with a few awkward exceptions in the last 5%. Bibliographic data seems like it’s all edge. It is inherently rotten with the influences of other languages, the strange ways of databases, and oddball conventions grandfathered in from Ye Olde Dayes. My own data collection methods varied over the years: what I kept and how I kept it has come back to haunt me.

I lost entire days to minutiae like accented characters, abbreviations, pagination punctuation, title casing methods, and so on. I nearly lost my mind trying to either hammer my data into the necessary shape, or write clever subroutines that would do the equivalent, or both.

And fairly often I just flat-out disagreed with the Vancouver system. It has some major flaws. My goal was to look like I know the standard — and I do now — but I’m not going to follow it off a typographic cliff.

Old versus new

So here’s an old citation…

Vibe-Fersum et al. Efficacy of classification-based cognitive functional therapy in patients with non-specific chronic low back pain: A randomized controlled trial. European Journal of Pain. 2013. PubMed #23208945.

There’s only one author listed, the journal spelled out instead of abbreviated, and there’s no date, volume, and issue data. Here’s the same paper cited Vancouver style…

Vibe-Fersum K, O'Sullivan P, Skouen JS, Smith A, Kvåle A. Efficacy of classification-based cognitive functional therapy in patients with non-specific chronic low back pain: A randomized controlled trial. Eur J Pain. 2013 Jul;17(6):916–28. PubMed #23208945.

Okay, admittedly it’s not a very exciting difference when all is said and done. It’s getting thousands of those to look right automatically that’s the impressive part.

100 good citation examples

There’s about 2500 items in the bibliography these days. 400 or so got some extra care and editing during the big upgrade. The 100 best and most interesting are listed here. (I can generate lists like this very easily, one of the superpowers of the system: I just tell the database to generate a score for each record by awarding points for things like how recent is, study quality, summary length, and keywords like “fun” and “odd” and “classic” and “good news.”)

A critical evaluation of the trigger point phenomenon

Spinal manipulation no better for back pain than placebos

Central sensitization

Functional Movement Screen unreliable

Adverse events and cervical manipulation for neck pain

Promising trial of cognitive functional therapy for low back pain

Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage

Forefoot runners have fewer injuries, but causality unclear

Neck strength can reduce chronic neck pain long-term

Regular Swedish versus “tensegrity-based” massage

Location of back and neck pain could not be detected by feel

More than 20% of manual therapy treatments do some harm

Cellular response to simulated myofascial release

Worn out shoes do change the biomechanics of running, but not much

Small, flawed trial of foam rolling shows 8% ROM increase

Comparison of 2 types of massage for chronic low back pain

Trial of therapeutic massage for neck pain

Brief, intense muscular training for cardiovascular fitness

Patellar maltracking in patellofemoral pain with patella alta

Why Most Published Research Findings Are False

Curcumin “likely” reduces muscle soreness after exercise

Thigh and hip exercises effective for patellofemoral pain

Increased trapezius pain sensitivity is not associated with increased tissue hardness

Regular hamstring stretching increased range of motion

The greatest hits of back pain science are a disappointment

Massage therapy probably helps patients with bone cancer

Flexibility gains due to changes in sensation, not muscle length

Safe but useless for knee arthritis: glucosamine, chondroitin sulphate, and celecoxib

The iliotibial band is uniformly, firmly attached to the femur

Intense, brief workouts almost as effective as time-consuming cardio

Trial of glucosamine for low back pain finds no therapeutic effect

Nerve root impingement fairly rare, barely more common in car accident victims

A fascinating landmark study of placebo surgery for knee osteoarthritis

The hazards of NSAIDs, especially diclofenac

Massage vs minimal exercise for poor circulation

Education, not core exercise, reduces back pain incidence in soldiers

Trigger points are acidic and contain pain-causing metabolites

8 weeks of core strengthening, coordination exercise for chronic low back pain

Do strong quadriceps help patellofemoral pain?

Surprisingly effective back pain injection: intradiscal methylene blue

Quality of online sports medicine information “highly variable”

Only quantity of exercise for back pain produces better results

Failed trial of vertebroplasty for compression fractures

Deyo and Weinstein’s 2001 low back pain tutorial

Disappointing first trial of surgery for tennis elbow

Regular, moderate exercise boosts makes neutrophils busier for longer

Yoga, stretching equally and slightly effective for back pain

Stress fractures: it’s not how hard you hit the ground, but how fast you hit it

Intravascular danger signals guide neutrophils to sites of sterile inflammation

Current evidence does not support Botox for trigger points

Online tutorials for chronic pain reduced pain, anxiety, disability

Prebiotics reduces waking cortisol response

Functional implications of the Q-angle in the patellofemoral joint

Botox for trigger points, update

Strong criticism of “more is better” strength training

Chiropractic subluxation is still “unsupported speculation”

Special core strengthening prevents no more injuries than ordinary sit-ups

Both heat and cold for back and neck strain mildly beneficial

Massage impairs post exercise muscle blood flow and lactic acid removal

General practitioners do not follow guidelines for low back pain care

A review of low quality evidence about exercise for neck pain

Chiropractic identity, role and future: survey

Is hip strength a risk factor for patellofemoral pain?

Regular physical activity prevents chronic pain

Stretching and heart rate variability in inflexible subjects

Smoking associated with low back pain, intervertebral disc disease

Cramps caused by effort, not dehydration and electrolyte shortage

Recent injury had no effect on FMS scores

Asymmetry of psoas and quadratus lumborum unrelated to injury

No clear benefit to muscle relaxants for acute neck strain

The science of trigger point diagnosis is a confusing mess so far

Myoglobin in plasma after trigger point massage

Cherries for soreness? Well, weakness at least

What causes the burn in intense muscle effort?

Dry needling for myofascial pain, review

A disturbing and typical example of sloppy modern acupuncture research

Promising results from athroscopic surgery for IT band syndrome

Does long-distance running lead to cartilage damage? An MRI study

Underwhelming: spinal adjustment and massage for back pain, neck pain

The effect of leg length on back pain: a classic test

Is exercise effective, or just efficacious?

Lumbosacral transition vertebra prevalence, significance

The Conundrum of Calcaneal Spurs

A major, comprehensive report on treatments for knee arthritis

Magnetic resonance imaging in follow-up assessment of sciatica

Minor benefits of pilates for chronic low back pain

Tuning fork, ultrasound diagnosis of stress fractures is unreliable

Hamstring flexibility cannot predict lumbar joint use in reaching

Women adapt effectively and minimally to wearing high heels

Acupuncture for back pain, a poor quality trial

Can trigger point therapy improve restricted ankle joint motion?

Review: patients are “highly satisfied” with physical therapy

Extremely thorough, valuable review of studies of back pain treatments

Stretching, strengthening don’t affect knee and shin injury rates in soldiers in basic training

Exercise reduces anterior knee pain risk

Prospective Predictors of Patellofemoral Pain Syndrome

Kinesio taping in treatment and prevention of sports injuries

Icing delays recovery from muscle soreness

Deep friction massage to treat tendinopathy: still no evidence

Fascia is too tough for mechanical deformation

[View this post on PainScience.com]

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