Ware, Ware, Hertfordshire SG12, UK
GlaxoSmithKline
Basic qualifications:
-Doctor of Veterinary Medicine (DVM) or equivalent veterinary degree
-Residency or other specialty training in anatomic, clinical, and/or toxicologic pathology
-Board certification (ACVP, ECVP, FRCPath, etc.)
Preferred qualifications:
-Ph.D. in an aligned scientific field
-Previous industry/CRO/experimental pathology experience
-Demonstrated organ/investigative/therapeutic area expertise.
Details:
UK Pathology ...
Based in Ware, the UK Pathology group at GSK are an experienced team of pathologists who design, examine and interpret toxicology studies and animal models for safety and efficacy. This includes evaluating in vitro or ex vivo specimens (e.g organoid or multi-dimensional tissue-based test systems, human biologic samples) to help integrate these developing technologies into pharmaceutical R&D practice. Pathologists are expected to seek new opportunities, by developing networks both within and outside GSK, to add scientific value from their discipline to the discovery and development of medicines.
Successful applicants for this position will join a well established worldwide GSK Pathology Community that regularly engages on a global basis to expand availability of specialized expertise (e.g. organ based, systems biology, discovery-oriented, or drug development specializations) as well as to strengthen the scientific discipline of pathobiology for application across the wide spectrum of therapy areas within GSK R&D.
Background of suitable applicants ...
We would be really interested in speaking to people who have worked in academia, Pharma or CROs and can bring demonstrable experience in evaluating animal models or ex vivo human tissues. At GSK we believe in developing talent and helping you grow within the organisation, if you can satisfy the basic academic requirements and show a level of scientific curiosity and practical experience, we would equally be interested in speaking with you.
Key Responsibilities ...
• Contribute to the design of in-vivo studies and provide histopathological examination, interpretation (including integration with clinical pathology, organ weight and other data) and reporting of investigative and regulatory toxicology studies on candidate biotherapeutics or small molecule entities to characterize safety or efficacy and enable decision-making or risk assessment in support of advancing these compounds to patients
• Apply comparative pathobiology knowledge, including current understanding of molecular and cellular biology, to support target selection, animal model development, non-animal alternative models, discovery safety and efficacy to improve candidate molecule quality, reduce late stage attrition and improve translation between preclinical and clinical findings
• Perform pathology peer review as directed to maintain consistency and quality of pathological evaluation and terminology both internally and also of contract research organizations.
• Collaborate with internal and external scientists in order to develop new technologies that may improve translation of drug discovery/ development findings to the clinic.
• Support and advise colleagues in the Histology Teams, as well as the Clinical Pathology and Diagnostics Teams
• Pursue continuing professional development and share knowledge, expertise and mentorship with others in order to ensure scientific integrity and progression of the Pathology and wider GSK vision.
• Ensure that all activities are carried out to the principles of GLP and to national and Company regulatory standards where applicable. Comply with all appropriate environmental health and safety regulations to ensure a safe working environment
• Provide expert pathology and/or veterinary advice to In Vivo Science and Delivery colleagues to ensure the highest standards of animal welfare are maintained.
• Provide expert pathology advice to Study Directors, Toxicology External Study Monitors, Project Team Members, Project Specialists to facilitate appropriate and timely decision making concerning GSK compounds.
• Contribute to the valuation of safety data on potential in-licensing candidates in order to assess their suitability for further development by GSK.
• Serve as Project Pathologist on assigned compounds, targets, and therapeutic areas
• Where appropriate, serve on multi-disciplinary program or project teams and oversee the progression of the project development plan at all phases according to project timelines and expectations for the role.
When applying for this role, please use the 'cover letter' of the on-line application to clearly describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter will be used to assess your application.
Thank you for your interest in this opportunity.
*LI-GSK
If requiring an adjustment for a disability, once selected for interview you may contact
Salary: . Date posted: 23/06/2016