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Oseltamivir phosphate (OP) is used to treat influenza virus infections. However, its use may result in central nervous system (CNS) adverse effects. In Japan, OP is used with Kampo formulations to improve clinical effectiveness. We evaluated the potential...

Given the limited understanding about pharmacokinetic-pharmacodynamic (PK-PD) determinants of oseltamivir efficacy, data from two phase 2 influenza virus inoculation studies were evaluated. Healthy volunteers in studies 1 and 2 were experimentally infected...

Patient Presentation A 2-year-old male came to clinic with a 24 hour history of fever to 102-103°, rhinorrhea, cough and what his parents believe were muscle aches. There was no nausea, emesis or rash. He was drinking but not eating solid foods and was...

ABOVE PICTURE-The synthetic route to tamiflu reported by M. Shibasaki starting from 1,4-cyclohexadiene. See JACS 2006, 128, 6312-6313     SEE  CHINESE ARTICLE ON  Recent Progress in the Synthesis of Tamiflu Zhang Tiancai, Lu Hui...

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