The Inositide laboratory
We are looking for a Research Fellow to use state of the art epigenetic studies and cell biological techniques to investigate how phosphoinositide signalling lipids impact on the function of epigenetic regulators to modulate nuclear functions such as transcriptional output and cell fate.
This research study is intended to investigate how a family of signalling lipids called phosphoinositides are regulated in the nucleus in response to environmental stimuli and how this impacts on cell behaviour by regulating epigenetic signalling and chromatin dynamics. The project will use state of the art molecular technologies such as CRISPR CAS and imaging studies to understand how phosphoinositides change in the nucleus. The fellow will collaborate with the Nuclear Dynamics groups headed by Dr. P. Fraser based at the Babraham campus in Cambridge to study the impact of changes in nuclear phosphoinositides on long range chromatin dynamics.
The applicant should have expertise in epigenetic signalling mechanisms and computational knowledge for the analysis of genomes and CHIP_seq data would be desirable.
Southampton University and Biological Sciences.
Southampton University is a world leading research university with 97% of its research work assessed as world leading and internationally excellent in the REF 2014 assessment. UOS is a Russell group member and its research impacts on government policy making, health issues, teaching and on business.
The work will take place at the main University campus, in Building 85, which was recently constructed (2008; £47M) to house Biological Sciences researchers, and those who conduct multidisciplinary research in any aspect of life sciences. This has led to the establishment of the Institute for Life Sciences (IfLS), highlighting the commitment of Southampton to research in the biological sciences. Biological Sciences houses the centre for imaging which is equipped with state of the art facilities for wide field, confocal and deconvolution imaging enabling live cell fluorescent imaging, FRET and FLIM analysis. It also encompasses the centre for proteomic research with state of the art technologies and methodologies for mass spectrometric enabling quantitative label free as well as ITRAQ analysis. The interdisciplinary centre for NMR offers the ability to collect data at both 600MHz and 400MHz in both solution and solid state and covering a multitude of nuclei. The facility routinely carries out work on small molecules, proteins, membrane systems and solid samples. Furthermore it forms part of the wider core facilities aimed at comprehensive solutions to investigations into protein structure providing a biomolecular analysis suite as well as comprehensive facilities for protein crystallisation and structure analysis. Next generation sequencing and bioinformatics analysis will be carried out in a new facility housed at the National Oceanography Centre.
Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.
This post is suitable for biochemists and cell biologists with an interest in epigenetic regulation .
For additional information/informal enquiries before submitting your application, contact Dr Nullin Divecha (n.divecha@soton.ac.uk).
At the University of Southampton, we value diversity and equality.
Application procedure
In your application, please include a covering letter and full CV, and please arrange for two letters of recommendation to be sent in by your referees.
You should submit your completed application form online at www.jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. References are requested along with your application, so please allow time for these to be received prior to the close date, to assist the department with shortlisting. If you need any assistance, please call Anna Shikhareva (Recruitment Team) on +44 (0) 23 8059 9002. Please quote vacancy reference number 809416BJ on all correspondence.
Closing Date: 16 Dec 2016
Post Type: Education, Research & Enterprise