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ATG9A is the only essential integral membrane protein involved in autophagy. ATG9A contains six transmembrane domains and initiates the assembly of autophagosomes. The autophagosome is a double-membrane structure that engulfs and eventually degrades...

Dr. Weeks’ Comment: Whole black cumin seeds as we as its extract thymoquinol (TQ) have anti-cancer benefits in general and quite impressively, against colon cancer in particular. Eat the Seeds to obtain optimal nutrition and all the health benefits of...

Mutations in PINK1 (PTEN-induced putative kinase 1) cause early onset familial Parkinson's disease (PD). PINK1 accumulates on the outer membrane of damaged mitochondria followed by recruiting parkin to promote mitophagy. Here, we demonstrate that BCL...

The PTEN-induced putative kinase protein 1 (PINK1) and ubiquitin (UB) ligase PARKIN direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the mitochondrial outer membrane (MOM) for ubiquitylation of MOM proteins with canonical...

Geoff Lecovin, MS, DC, ND, CSCS, NASM-CPT, CES, PES Looking for ways to boost your metabolism? Try a biohack! Here’s 5 simple biohacks to get your body’s engine revving! From the power of sleep, to diet and exercise, see how easy it can be. Biohacking...