2015-06-19

Quantitation of Endothelial Cell Adhesiveness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό



In Vitro via JoVE: Journal of Visualized Experiments [image: 52924fig1.jpg] We report an in vitro method that allows the quantitation of the actual number of adhesive cells within an endothelial cell monolayer.

The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

in head and neck squamous cell carcinoma via ScienceDirect Publication: Radiotherapy and Oncology Publication date: Available online 18 June 2015 *Source:*Radiotherapy and Oncology Author(s): Oscar Matzinger , David Viertl , Pelagia Tsoutsou , Linda Kadi , Stefania Rigotti , Claudio Zanna , Norbert Wiedemann , Marie-Catherine Vozenin , Grégoire Vuagniaux , Jean Bourhis Background and purposeSecond mitochondria-derived activator of caspase (SMAC)-mimetics are a new class of targeted drugs that specifically induce apoptotic cancer cell death and block pro-survival signaling by antagoniz... περισσότερα »

Identifying patients who may benefit from adaptive radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help? via ScienceDirect Publication: Radiotherapy and Oncology *Source:*Radiotherapy and Oncology Author(s): Charlotte L. Brouwer , Roel J.H.M. Steenbakkers , Johannes A. Langendijk , Nanna M. Sijtsema In the last decade, many efforts have been made to characterize anatomic changes of head and neck organs at risk (OARs) and the dosimetric consequences during radiotherapy. This review was undertaken to provide an overview of the magnitude and frequency of ... περισσότερα »

Acute febrile respiratory infections in hospitalized children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

Molecular viral epidemiology and clinical characterization of acute febrile respiratory infections in hospitalized children in Taiwan by Chun-Yi Lee, Yu-Fen Chang, Chia-Lin Lee, Meng-Che Wu, Chi-Lin Ho, Yu-Chuan Chang, Yu-Jiun Chan via Journal of Medical Virology Abstract Acute respiratory infection (ARI) is a leading cause of morbidity and hospitalization in children. To profile the viruses causing ARI in children admitted to a community-based hospital in central Taiwan, a cross-sectional study was conducted on children under 14 years of age that were hospitalized with febrile ARI. V... περισσότερα »

Fetal radiation dose from [18F]-FDG in pregnant patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

imaged with PET, PET/CT and PET/MRI by Zanotti-Fregonara, P., Laforest, R., Wallis, J. W. via JNM Ahead of Print The fetal radiation dose from 18F-FDG was estimated in a series of pregnant women who underwent a PET scan during the clinical workup for malignancies *Methods:* Six pregnant patients were injected with 328 ± 38 MBq of 18F-FDG. Three patients were scanned during the first trimester (one with PET and two with PET/CT), two during the second trimester (with PET/MRI) and one during the third (with PET). The time-integrated activity coefficients were derived from the fetal radi...περισσότερα »

Prognostic value of pretherapeutic tumor-to-blood standard uptake ratio (SUR)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα

in patients with esophageal carcinoma by Butof, R., Hofheinz, F., Zophel, K., Stadelmann, T., Schmollack, J., Jentsch, C., Lock, S., Kotzerke, J., Baumann, M., van den Hoff, J. via JNM Ahead of Print Despite ongoing efforts to develop new treatment options the prognosis for patients with inoperable esophageal carcinoma is still poor and the reliability of individual therapy outcome prediction based on clinical parameters is not convincing. The aim of this work was to investigate if PET can provide independent prognostic information in such a patient group and if the tumor-to-blood s... περισσότερα »

Staphylococcal Enterotoxin B in the Pathogenesis of Autoimmune Diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

Possible Role of by Jing Li via Viral Immunology - Table of Contents Viral Immunology , Vol. 0, No. 0. Author information Jing Li,1,* Jie Yang,1* Yu-wei Lu,2 Song Wu,1 Ming-rui Wang,1 and Ji-min Zhu 1 1Department of Public Health and General Medicine, School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei, China. 2Department of Information, The Second Hospital of Anhui Medical University, Hefei, China. *These authors contributed equally to this work. Address correspondence to: *Dr. Ji-min Zhu* *Department of Public Health and General Medicine...περισσότερα »

A Comparison of 4D DSA with 2D and 3D DSA in the Analysis of Normal Vascular Structures

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα

in a Canine Model [INTERVENTIONAL] by Sandoval-Garcia, C., Royalty, K., Aagaard-Kienitz, B., Schafer, S., Yang, P., Strother, C. via Neuroradiology BACKGROUND AND PURPOSE:4D DSA allows viewing of 3D DSA as a series of time-resolved volumes of a contrast bolus. There is no comparison of the accuracy of the anatomic information provided by 4D DSA with that available from conventional 2D and 3D DSA. Our purpose was to make this comparison by using a canine model. MATERIALS AND METHODS:2D, 3D, and 4D DSA acquisitions were performed in 5 canines from 3 catheter positions in the common car... περισσότερα »

Acute Basilar Occlusions with Underlying Severe Intracranial Vertebrobasilar Stenosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

Combined Use of Mechanical Thrombectomy with Angioplasty and Stenting for Acute Basilar Occlusions with Underlying Severe Intracranial Vertebrobasilar Stenosis: Preliminary Experience from a Single Chinese Center [INTERVENTIONAL] by Gao, F., Lo, W. T., Sun, X., Mo, D. P., Ma, N., Miao, Z. R. via Neuroradiology BACKGROUND AND PURPOSE:Acute basilar occlusions have a poor prognosis without recanalization. Many have underlying severe atherosclerotic intracranial stenosis coexisting with acute thrombosis, requiring treatment of both pathologies in the same session, though technical risks ... περισσότερα »

A miRNA-based signature predicts development of brain metastasis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα

A miRNA-based signature detected in primary melanoma tissue predicts development of brain metastasis by Hanniford, D., Zhong, J., Koetz, L., Gaziel-Sovran, A., Lackaye, D. J., Shang, S., Pavlick, A., Shapiro, R. L., Berman, R. S., Darvishian, F., Shao, Y., Osman, I., Hernando, E. via Clinical Cancer Research Online First Articles Purpose: Brain metastasis is the major cause of mortality among melanoma patients. A molecular prognostic test that can reliably stratify patients at initial melanoma diagnosis by risk of developing brain metastasis may inform the clinical management of thes... περισσότερα »

Donate to Food Redistribution Organisations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

Sustainability, Vol. 7, Pages 7997-8021: Charity Starts … at Work? Conceptual Foundations for Research with Businesses that Donate to Food Redistribution Organisations updated at 12:41 by Elisha Vlaholias via MDPI Publishing As global concern about sustainability, food waste, and poverty increases, there is an urgent need to understand what motivates businesses to adopt pro-social and pro-environmental behaviours. This paper suggests that food redistribution organisations hold both pro-social and pro-environmental aims, due to their concern with reducing food surplus and food insecuri...περισσότερα »

Facial dysmorphism,microcephaly,brain atrophy,camptodactyly,bilateral renal atrophy with chronic kidney disease,renal cyst

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα

Distal 10q trisomy with copy number gain in chromosome region 10q23.1–10q25.1: the Wnt signaling pathway is the most pertinent to the gene content in the region of copy number gain: a case report by Siew-Lee Wong via BMC Research Notes - Latest Articles Background: Complete or partial trisomy 10q involves a duplication of 10q, or the long arm of chromosome 10. Distal 10q trisomy is a well-recognized and defined but rare genetic syndrome in which duplication of distal segments of 10q results in a pattern of malformations. Although abnormal chromosome phenotypes are commonly detected by...περισσότερα »

Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Antibiotics, Vol. 4, Pages 216-229: Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection by Yuan-Pin Hung via MDPI Publishing Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivatives such as tetracycline, doxycycline or tigecycline are not the standard therapeutic choices for CDI, they may serve as an alternative or a component of combin...περισσότερα »

Experimental Animal Models of Arteriovenous Malformation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Veterinary Sciences, Vol. 2, Pages 97-110: : A Review by Jude Raj via MDPI Publishing Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM...περισσότερα »

Essential Oils Inhibit Biofilm Mass Production by Multi-Drug Resistant Staphylococcus aureus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Molecules, Vol. 20, Pages 11357-11372: Individual Constituents from by Laura Espina via MDPI Publishing Biofilm formation by Staphylococcus aureus represents a problem in both the medical field and the food industry, because the biofilm structure provides protection to embedded cells and it strongly attaches to surfaces. This circumstance is leading to many research programs seeking new alternatives to control biofilm formation by this pathogen. In this study we show that a potent inhibition of biofilm mass production can be achieved in community-associated methicillin-resistant S. a...περισσότερα »

3D Printable Biophotopolymers for in Vivo Bone Regeneration

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα

Materials, Vol. 8, Pages 3685-3700: by Guenter Russmueller via MDPI Publishing The present study investigated two novel biophotopolymer classes that are chemically based on non-toxic poly (vinyl alcohol). These vinylesters and vinylcarbonates were compared to standard acrylates in vitro on MC3T3-E1 cells and in vivo in a small animal model. In vitro, both vinylester and vinylcarbonate monomers showed about tenfold less cytotoxicity when compared to acrylates (IC50: 2.922 mM and 2.392 mM vs. 0.201 mM) and at least threefold higher alkaline phosphatase activity (17.038 and 18.836 vs. ... περισσότερα »

Gaze-Assisted User Intention Prediction for Initial Delay Reduction in Web Video Access

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Sensors, Vol. 15, Pages 14679-14700: by Seungyup Lee via MDPI Publishing Despite the remarkable improvement of hardware and network technology, the inevitable delay from a user’s command action to a system response is still one of the most crucial influence factors in user experiences (UXs). Especially for a web video service, an initial delay from click action to video start has significant influences on the quality of experience (QoE). The initial delay of a system can be minimized by preparing execution based on predicted user’s intention prior to actual command action. The intro...περισσότερα »

Sodium Selenite in the Treatment of Patients with Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Nutrients, Vol. 7, Pages 4978-4994: Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study by Ola Brodin via MDPI Publishing Background: Sodium selenite at high dose exerts antitumor effects and increases efficacy of cytostatic drugs in multiple preclinical malignancy models. We assessed the safety and efficacy of intravenous administered sodium selenite in cancer patients’ refractory to cytostatic drugs in a phase I trial. Patients received first line of chemotherapy following selenite treatment to in... περισσότερα »

Calcitriol in Cancer Biology

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 26 δευτερόλεπτα

Nutrients, Vol. 7, Pages 5020-5050: Mechanistic Effects of Calcitriol in Cancer Biology by Lorenza Díaz via MDPI Publishing Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we ad... περισσότερα »

The cortico-basal ganglia system in value-based learning

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα

Computing reward prediction error: an integrated account of cortical timing and basal-ganglia pathways for appetitive and aversive learning by Kenji Morita, Yasuo Kawaguchi via European Journal of Neuroscience Abstract There are two prevailing notions regarding the involvement of the cortico-basal ganglia system in value-based learning: (1) the direct and indirect pathways of the basal ganglia are crucial for appetitive and aversive learning, respectively, and (2) the activity of midbrain dopamine neurons represents reward-prediction-error. While (2) constitutes a critical assumption ... περισσότερα »

Treatment-emergent hypocalcaemia in patients with bone metastases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

treated with denosumab via European Journal of Cancer *Source:*European Journal of Cancer Author(s): Jean-Jacques Body , Henry G. Bone , Richard H. de Boer , Alison Stopeck , Catherine Van Poznak , Ronaldo Damião , Karim Fizazi , David H. Henry , Toni Ibrahim , Allan Lipton , Fred Saad , Neal Shore , Toshimi Takano , Adam J. Shaywitz , Huei Wang , Oswaldo L. Bracco , Ada Braun , Paul J. Kostenuik BackgroundThis analysis was performed to further characterise treatment-emergent hypocalcaemia in patients with bone metastases receiving denosumab.MethodsLaboratory abnormalities and adver... περισσότερα »

Chlorhexidine Anaphylaxis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα

Masquerading as Septic Shock via IAA : Last 10 articles Chlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Its usage has increased in recent years with intensive campaigns and infection control guidelines to combat hospital-acquired infections. As a result, patients and health-care workers (HCW) are exposed to increasing chlorhexidine usage. In recent years, adverse reactions to chlorhexidine ranging from allergic contact dermatitis, photosensitivity, fixed drug eruptions, urticaria and anaphylactic shock have been reported. Most have been isola...περισσότερα »

Lactase deficient population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 32 δευτερόλεπτα



Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices by X. Zheng, H. Chu, Y. Cong, Y. Deng, Y. Long, Y. Zhu, D. Pohl, M. Fried, N. Dai, M. Fox via The European Gastrointestinal Motility Society Abstract Background Many patients complain of abdominal symptoms with dairy products; however, clinical and psychosocial factors associated with self-reported lactose intolerance (SLI) have not been assessed in large studies. In particular, data are lacking from lactase deficient populations. This pr... περισσότερα »

Rotational (video head impulse – vHIT) and caloric tests in patients with Ménière’s disease (MD)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα

What does the dissociation between the results of video head impulse versus caloric testing reveal about the vestibular dysfunction in Ménière’s disease? by Leigh A. McGarvie et al via Acta Oto-laryngologica Acta Oto-laryngologica, Ahead of Print. Leigh A. McGarvie, Ian S. Curthoys, Hamish G. MacDougall, and G. Michael Halmagyi 1Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown NSW , Australia 2Vestibular Research Laboratory, School of Psychology, University of Sydney , NSW , Australia Correspondence: Dr Ian S. Curthoys, Vestibular Research Laboratory, Sch... περισσότερα »

Videoendoscopic Evaluation of Swallowing After Thyroidectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

: 7 and 60 Days via Dysphagia AbstractDeglutition complaints are frequent after thyroidectomy. The purpose of this study was to follow-up on patients with thyroidectomy indication to compare the videoendoscopic evaluation of swallowing on the seventh day (early postoperative, EPO) and on the 60th day after thyroidectomy, (late postoperative, LPO) and to compare patients that evolved with normal laryngeal mobility (NLM) and abnormal laryngeal mobility (ALM). Nasofibroscopic evaluation was performed preoperatively (PRE), on the EPO and LPO. Two groups were compared: ALM and NLM. The m...περισσότερα »

Cancer-associated facial pain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα

Cancer and Referred Facial Pain via Headache Reports Abstract Orofacial pain may be a symptom of diverse types of cancers as a result of local or distant tumor effects. The pain can be presented with the same characteristics as any other orofacial pain disorder, and this should be recognized by the clinician. Orofacial pain also can arise as a consequence of cancer therapy. In the present article, we review the mechanisms of cancer-associated facial pain, its clinical presentation, and cancer therapy associated with orofacial pain. Intranasal sufentanil for *cancer*-*associated *brea... περισσότερα »

Giant Cell Arteritis,Unilateral Anterior Ischemic Optic Neuropathy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Giant Cell Arteritis Presenting as Unilateral Anterior Ischemic Optic Neuropathy Associated With Bilateral Optic Nerve Sheath Enhancement on Magnetic Resonance Imaging. by Liu, Tin Yan A.; Miller, Neil R. via The North American Neuro-Ophthalmology Society A 67-year-old man developed jaw claudication followed by loss of vision in the left eye caused by anterior ischemic optic neuropathy (AION). An erythrocyte sedimentation rate was normal, but C-reactive protein was slightly elevated. Although the patient had no evidence of a right optic neuropathy, magnetic resonance imaging (MRI) re...περισσότερα »

H2S on esophageal motility

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα


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