*Org Marketing Statement*
All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That’s why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place.
*Role Description*
The candidate will be an integral member of drug discovery design teams, working closely with medicinal chemists and other project team colleagues (Biology, Structural Biology, Drug Metabolism, Drug Safety, etc.). The candidate will be expected to generate scientific hypotheses and apply computational strategies to assist small molecule design. Additional expectations include developing and deploying novel computational methods and workflows to improve computational chemistry discipline productivity as evidenced by project impact. A strong understanding of fundamental theory and familiarity with one or more modern software package(s) and computational tools is required.
*Responsibilities*
As an independent researcher and integral member of project teams, the candidate will be responsible for determining the appropriate computational techniques to drive drug design decisions. The position involves the generation and testing of scientific hypotheses through the application of a wide variety of computational approaches including: structure-based drug design, ligand-based design, pharmacophore modeling, file mining, docking, HTS analysis, QSAR and in silico ADME/Tox modeling along with the design of specific small molecules. The position also involves the development of novel computational approaches to solve specific or general problems in drug discovery.
*Qualifications*
Education and Experience:
A Ph. D. in computational chemistry or relevant discipline with 2-3 years post-doctoral experience is preferred. Experience working as a computational chemist in the pharmaceutical industry is a plus.
Technical Skills Requirement:
• Extensive depth/breadth of knowledge in one or more areas of the computational chemistry discipline (e.g., structure-based design, molecular dynamics, ligand-based design, quantum mechanics, QSAR, homology modeling, pharmacophore modeling, estimating protein-ligand affinity, etc.)
• Basic knowledge in other Comp Chem specialty areas, Medicinal Chemistry, Drug Safety, Structural Biology, Chemical Biology, Pharmacokinetics/Pharmacodynamics, Computational Biology and Bioinformatics.
• Deep knowledge of oncology targets (kinases, immunology, epigenetics, etc.) is a plus.
• Demonstrates consistently high level of skills and knowledge in at least one modeling software tool/package (e.g., Schrodinger, MOE, OpenEye, Accelrys, AMBER, etc) and computational techniques.
• Sound knowledge of Linux environment and practical experience in one or more scripting and/or programming language such as cshell, Python, Perl, C, C++, etc. Skills in statistics or statistical modeling are valuable. Facility with Pipeline Pilot and/or Spotfire is a plus.
• Excellent communication and time management skills.
• Demonstrated ability to work in high energy and a multi-disciplinary team environment.
*EEO & Employment Eligibility*
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
*Sunshine Act*
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
*Computational Chemist (Oncology)*
*La Jolla, California*
*1012462*