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To understand the regulatory role of niches in maintaining stem-cell fate, multifactorial in vitro models are required. These systems should enable analysis of biochemical and biophysical niche effectors in a combinatorial fashion and in the context...

The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian aPKCs control stem cells and fate in vivo is not known. Here we show that loss of aPKC in a self-renewing epithelium, the...

Study results could lead to engineering human cells and tissues, researchers say WEDNESDAY, Aug. 31, 2016 (HealthDay News) — Researchers say they’ve found an easy way to spur stem cells to build bone in mice — a discovery that could lead to new treatments...

Adding adenosine to human pluripotent stem cells’ growth medium may coax them into regenerating bone tissue, according to a recent study. Investigating this method on mice, the scientists suggest that the stem cell-derived bone tissue helped repair...

When most cells divide, they simply make more of themselves. But stem cells, which are responsible for repairing or making new tissue, have a choice: They can generate more stem cells or differentiate into skin cells, liver cells, or virtually any of...