Biomarkers and Ageing
Tuesday, 25 February 2015
Cineworld: The O2, London, SE10 0DX, UK
www.regonline.co.uk/biomarkage2014
Biomarkers of ageing could help to characterise biological age and be used, not only to identify individuals at high risk of developing age-associated diseases or disabilities, but also could lead to anti-ageing therapies. This event will discuss the current research to identify and characterise biomarkers for ageing in an informal atmosphere. Abstract submissions are encouraged for both oral and poster presentations and there will be plenty of opportunity of networking with experts in the field. Part of the 2014 Ageing Summit: www.AgeingSummit2014.com. This event has CPD accreditation.
Meeting Chairs: Professor David Melzer and Dr Lorna Harries, Epidemiology & Public Health Group, Medical School, University of Exeter, UK
Abstracts for poster presentation only can be submitted up to two weeks before the event. You can download the instructions for authors at : www.euroscicon.com/AbstractsForOralAndPosterPresentation.pdf
Talk times include 5 – 10 minutes for questions
9:00 – 9:45 Registration
9:45 – 10:00 Introduction by the Chairs: Professor David Melzer and Dr Lorna Harries, Epidemiology & Public Health Group, Medical School, University of Exeter, UK
10:00 – 10:30 Bone turnover markers and ageing-related loss of bone mass and strength
Dr Pawel Szulc, INSERM UMR 1033, University of Lyon, France
In postmenopausal women and in older men, elevated BTM levels (which reflect higher bone turnover) are associated with lower BMD, poor bone microarchitecture (e.g. thinner cortex) and faster bone loss. Bone turnover rate is a major determinant of bone loss in older people. However, BTM measurement cannot be used for prediction of accelerated bone loss, because their correlation is not strong enough, especially in men. Higher BTM levels are associated with higher risk of fracture (i.e. lower bone strength). This association was found in postmenopausal and elderly women, but not older men. It was found mainly for major osteoporotic fractures (e.g. hip fracture), especially in short-term follow-ups (<5 years). This association was significant only for bone-specific BTM, mainly for bone resorption markers. The association between BTM levels and fracture risk remains significant after adjustment for BMD, which indicates that accelerated bone turnover is an independent determinant of bone fragility. However, currently, there are no official guidelines concerning the use of BTM for the fracture risk assessment in the clinical practice. In conclusion, measurement of BTM can improve our understanding of the mechanisms leading to the ageing-related loss of bone mass and strength.
10:30 – 11:00 Maldi imaging mass spectrometry of ageing cartilage
Dr Mandy Peffers, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
11:00 – 11:30 Speakers’ photo then mid-morning break and poster exhibition and trade show
11:30 – 12:00 Healthy ageing: are we there yet?
Dr Suzanne Wait, Director, SHW Health Ltd, UK
‘Healthy ageing’ has become a ubiquitous goal in all countries facing the challenges of an ageing population. This talk will provide an overview of the current epidemiology of ageing — looking at time trends, changing patterns of morbidity and co-morbidity, quality of life and independence, and the implications of these trends on health and social policies. Changes that are needed within health and social care systems will be explored with a view to define ways in which we can best foster the healthy ageing of our populations in the future.
12:00 – 12:30 Interpretation and usefulness of current reference intervals for biochemical markers in multi-diseased elderly.
Maria Edvardsson, Finspång Health Care Centre, County Council of Östergötland, Sweden.
12:30 – 13:30 Lunch, poster exhibition and trade show
13:30 – 14:30 Discussion Panel
This discussion session is an informal question and answer session. This is an ideal opportunity to get advice and opinion from experts in this area. This session is not for questions about specific talks, which can be asked after the speakers session, but for discussing either general topics or specific issues. There are three ways you can ask questions:
1. Before the session you can submit your question to Euroscicon staff at the registration desk,
2. Before and during the session you can submit a question or comments, by email, which will be provided on the day of the event
3. During the session you can put your hand up and join in
14:30 – 15:00 Talk title to be confirmed
Dr Rachel Watson, Senior Lecturer, Centre for Dermatology, Institute of Inflammation & Repair, The University of Manchester
15:00 – 15:30 Afternoon Tea, last poster session and trade show
15:30 – 16:00 Genomic biomarkers of human ageing
Professor David Melzer, Epidemiology & Public Health Group, Medical School, University of Exeter, UK
16:00 – 16:30 Individual features of adaptive behavior and biomarkers for primate ageing
Professor Nadezhda Goncharova, Head of the Lab.of Endocrinology, Research Institute of Medical Primatology of the Russian Academy of Medical Sciences; Sochi State University, Russia
The identification of markers of individual vulnerability to stress and aging is one of the most significant problems of personalized medicine. Studying the response of adaptive systems to stress and aging in individuals, depending on the typological characteristics of their adaptive behavior is a useful approach to this problem. The purpose was to investigate age-related changes in the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and the erythrocyte antioxidant enzyme system (AES) in monkeys with various types of adaptive behavior (depression-like, aggressive, and standard). We have found that age-related dysfunctions in the HPA axis and AES are maximal in monkeys with depression-like behavior.
16:30 – 17:00 Chairman’s summing up
Registration Website: www.regonline.co.uk/biomarkage2014
About the Speakers
Pawel Szulc, M.D., Ph.D., graduated from the Medical Faculty in Warsaw, 1986. Researcher in the INSERM UMR 1033, Lyon, France. Member of the Committee of Scientific Advisors of the International Osteoporosis Foundation. Member of the Editorial Board of Osteoporosis International. Member of American Society for Bone and Mineral Research, International Bone and Mineral Society, International Society for Men’s Health. Member of the Thematic Network on the Osteoporosis in Male (2001-06). Scientific interests: osteoporosis, sarcopenia, relationship between osteoporosis and cardiovascular diseases. Author of 60 papers and chapters concerning osteoporosis, mainly osteoporosis in men, bone turnover markers and vertebral fracture. Fellowships: French Government (1991) and European Community (1993).
Suzanne Waitis Director of SHW Health, a London-based consultancy which provides expert advice on policy analysis and implementation to non-profit, governmental and private sector clients. Her work has focused on a broad range of topics, including ageing, diabetes, stroke prevention, viral hepatitis, health literacy, and integrated care. Suzanne is a former Director of Research of the International Longevity Centre-UK, where she remains an Advisor. She taught at the UCL School of Public Policy for 5 years and has over 30 peer-reviewed publications. She has a PhD from the university of Strasbourg and a Masters in Public Health from Columbia University.
Nadezhda Dmitrievna Goncharova, biochemist, endocrinologist. Graduated from Kharkov State University, Department of Biochemistry, Master Degree – Biology (Diploma with Honor), Kharkov, Ukraine (former USSR),1973.Ph.D. (Candidate of Biological Sciences – Biochemistry), 2th Moscow State Pirogov`s Medical Institute, Moscow, 1981; Sci. D. (Doctor of Biological Sciences – Pathological Physiology), Highest Attestation Committee, Moscow, 1997. Worked at the Institute of Experimental Pathology and Therapy of the Academy of Medical Sciences (Sukhumi, Georgia, former USSR) in 1973-1993; Research Institute of Medical Primatology of the Russian Academy of Medical Sciences (IMP RAMS, Sochi, Adler, Russia) in 1993-present. Since 1997, head of the laboratory of endocrinology in the IMP RAMS. Related Experience: Sochi State University, Department of Biomedical Sciences, Sochi, professor.
Post expires at 12:05pm on Friday January 25th, 2013