Aromatization
let's talk about the universal principles of Aromatization
Aromatization is the process by which the body converts anabolic steroids and/or testosterone into what? That's right,Estrogen!.
By now this is something that either most of us know,or some are just learning about..But whats not being explained is the reason why?
It's crucial that we understand exactly what is going on...
First and foremost, the principles that govern our body,The human body loves balance. Have you ever heard of the term "homeostasis"?
The term homeostasis represents the dynamics within the body and it's will to regulate the systems within the body.
The body/system/endocrine likes to dictate and micromanage everything: From fat levels, to hormones,muscle mass, your neurotransmitters, and basically your overall body-weight, and keep these in a narrow range.
Fact of the matter is, There's many,many systems of checks and balances within the body. If/when one fails, there is usually another one that will intervene and assist...
Let's take the instance that aromatization is in the process due to AAS, now the body will begin to convert some of the exogenous (whether the introduction comes in the form of injection/IM/Sub-Q,or an oral administration) hormone that come from an outside source, into estrogen to try and keep a balance between male and female hormone/sex hormones in the system/endo. With this being said, even the male body contains natural amounts of the female hormones estrogen and progesterone. However, what the male body does NOT posses (( In most cases )) is enormous amounts of hundreds and in some cases thousands of milligrams of testosterone floating around. The average healthy male who does not have carry a set of Rino-Nuts between his legs can/may produces on/around 4-7mg per day { typically at peek in the morning,a reason why most of us don't want coffee nor a shower first things }..Back on subject, That's merely around 40-50 milligrams per week. So, with this being said, what exactly do YOU think happens when we dump 250,500+ milligrams of test into our system??? I hope you guessed right..Your estrogen (E2) goes up...Why? Because It has to, back to the term "Homeostasis" the universal principles on how the body likes balance and narrow ranges,Do you understand now?
What's crucial here is getting bloods (lab work) done,pre,mid,and post-cycle.. This way you have a good indicator of where you are and what's going on with your hormonal levels..This is key to knowing how to treat/combat your E1/E2 "estrogen and progesterone"
Now,What to do about this excess estrogen? Here's the thing, if/when estrogen goes up but yet stays in "proportion" to the increased amount of testosterone, you don't have to worry too much here. However If for some reason,your the unlucky and your genetics produce an enzyme called aromatase, you could have a potential issue on hand.. (By now you should get the idea on where I'm going with this).
Aromatase is an enzyme that will manipulate test,by converting testosterone into estrogen as its primary function,yielding it as it's pivotal roll. The more aromatase you posses in your system, the more testosterone to estrogen conversion you will have as well.
Many people have asked me the following- "How do I know if I'm genetically prone or posses high aromatase levels naturally? Unfortunately,You don't know. You can't,there is no real indicator/test to check for this,and at most cases it's a bit to late by the time you find out (side effects,itchy sore nipples,or worst,lactating ducts)..Unless you have a precondition known as (AES or AEXS) Aromatase excess syndrome..If that was the case,you would be familiarized with everything that I'm discussing here!
Where is all this leading up to?
Gyno (gynocomastia),one of the most dreaded words in all of the Anabolic communities/gyms!
What's a key factor here is,knowing your compounds and what drugs are most commonly affiliated with gynocomastia (bitch tits)..To name a few-Methandrostenolone (dianabol) (both liquid and pill), Oxymetholone (anadrol)..And all testosterone esters (yes, even prop), test suspension..And for some users -Nandrolone (Deca)..
With this being said,the most important thing here is what pertains to the aromatization of testosterone/or other compounds into estrogen. The ratio of testosterone to estrogen is what determines how severe your chances are for developing serious estrogenic affects such as gyno/bloat ext... So what do you do to combat this if you are susceptible to gyno/estrogenic effects? Your answer lies in proper use and understanding of anti-estrogen and anti-aromatase drugs,getting BLOOD WORK DONE,and timing your compounds and being proactive and prepared!
Regards,
Vision
Below is some basic info pasted to add to the above abstract
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Anti-Estrogens
Anti-estrogens can be crucial to safe and effective anabolic steroid usage. There are a few key purposes to use them, and a few untraditional yet valuable alternative usages as well. We will go over both. Most of the uses vary due to the different mechanism of action for each drug; the way they work. Depending on the mechanism of action, a given anti-estrogen drug may be more or less suited to your unique need.
As a side note, in some of these explanations, the chemical and medical literature will not be the same as you will find in genuine text books on the dry topics. We are using these terms with strict purpose of understanding the physiology and biochemistry of anabolic steroids for our purposes. Please keep this in mind.
Anti-estrogens work in a few basic ways. The first is to block the estrogen receptor itself. This is known as a second line inhibitor because estrogen is allowed to be produced, it is just blocked at the receptor. This occurs by the anti-estrogenic drug fitting into the estrogen receptor, and ?taking its parking space?. When the original estrogen comes along, it can no longer fit into the receptor. Examples of second line inhibitor drugs would be clomid or nolvadex. Both of these drugs are actually estrogens, they are just so weak that they do not elicit any of the negative effects of the true estrogen, and thereby, block the negative estrogenic effects. These are also two of the most known drugs since the athletic usage of anabolic steroids began.
First line inhibitors are drugs such as arimidex and proviron. Although these two drugs are from different chemical classes, they are both first line inhibitors. Proviron is actually a steroid with zero direct anabolic activity. As we will soon describe, proviron has other benefits aside from its anti-estrogenic activity. It is used clinically to replace androgens in the male for the purpose of sex drive and virility. Arimidex is a drug which is a chemical antagonist. For the purpose of estrogen talk, we can consider first line inhibitors and chemical antagonists to be the same. What is meant by this, is, the estrogen is inhibited at site of production, not at the receptor. Both arimidex and proviron will bind to the aromatase enzyme and render it inactive. Without the aromatase enzyme the body cannot convert various anabolics into estrogen. Estrogen is essentially blocked at its root, where it is originally produced.
First line inhibitors are usually a more effective and potent method of estrogen control. The disadvantage is that the first line inhibitors will usually not do much for whatever estrogen is already present in the system. It will only work on preventing further amounts of excess estrogen from being produced. In practical terms, this will result in a delay from days? to weeks? time before a significant anti-estrognic affect is seen. This is fine if you are just using it as precaution, but if you need immediate anti-estrogen activity due to excessive bloat or, you will want to take a second line inhibitor such as clomid or nolvadex immediately. Once the immediate estrogen is under control, you can add in the first line inhibitors to prevent further accumulation of estrogen metabolites in your system.
Here is a little more detail about these most popular anti-estrogens in order to help you choose how and when to use which:
Nolvadex
Nolvadex is one of the most well known anti-estrogens. It is also one of the oldest and most popular medications for breast cancer victims, which is the text book clinical use for this drug. Nolvadex is actually a weak estrogen and will bind to the estrogen receptor. The receptor is then occupied and when the normal and stronger estrogen floats by the receptor, it has no where to ?park?. This is what we have defined as the classic second line inhibitor. Second line, because we are allowing estrogen to be produced, we are just blocking it at the receptor. For male usage, nolvadex is a good drug of choice to use for ant-bloating and to control gyno if you are not particularly susceptible to these estrogenic side effects. If you are not and just need minor control, 20mg per day is probably enough to keep the majority of water off and your nips from being sensitive. If you are susceptible, you may need a stronger ant-estrogen, or may need to combine nolvadex with another anti-estrogenic drug, or may need a much higher dosage of nolvadex (probably closer to 40mg/day).
There is some literature out there that states nolvadex having better leutinizing (testosterone stimulating) properties than clomid. This is with respect to post cycle recovery and jump starting your natural testosterone. Personally, amongst all my friends and colleagues, I have not found this to be true. With respect to post cycle recovery of natural testosterone production clomid is definitely more effective.
Clomid
As we?ve stated above, clomid is more effective at restoring natural testosterone production. Everything you read about these two drugs seems to offer the same info. I will afford you with something different. For anti-estrogen protection, nolvadex is probably a little stronger. Its chemical structure makes for a slightly more potent anti-estrogen. I have yet to see any quality literature which describes the affinity for either drug at the estrogen receptor. Clomid after all, is also a weak estrogen. Another term used to classify clomid and nolvadex is ?competitive inhibitor?. They are so called due to the fact that they are weak estrogens and actually bind to the receptor. By doing this they are competing for the ?parking spot? in the receptor, thereby occupying the space when the truer, stronger estrogen comes along. Its like being at the local mall and having someone pull around the isle, cut you off and take your spot. In a sense they just ?competed? with you for your spot and ?inhibited? you from taking it. Got it? Good. See this stuff is simple, my fellow friends and athletes.
The literature also fails to describe exactly why clomid works more efficiently as a leutinizer. Even in the medical literature, the drug is primarily used for fertility purposes for both males and females. This means clomid has value in stimulating the pituitary in both men and women. Clomid is used on a five day course in order to stimulate ovulation in the female in order to enable fertilization. There is not a fertility doctor in the world that doesn?t know what clomid is. It is a drug that has always been in their toolbox. Part of the reason is, it works. The literature is less extensive for fertility cases in the male but know that it is indeed used for this purpose. Now, as much as I am all for underground self taught knowledge, we have to hand it to the medical professionals for specific cases. For example, if nolvadex were a better leutinizer, it would be the drug of choice in fertility clinics for stimulating ovulation in the female and for aiding fertility and motility of sperm in the male. Simple fact is that this is not the case. Save your self time and frustration by using a medically time tested drug for your post cycle recovery of testosterone. For recovery of your natural test, use clomid.
Arimidex
Arimidex is called a chemical inhibitor of estrogen. Actually, it is a chemical inhibitor of the enzyme aromatase. Arimidex has a high affinity (liking for) for the aromatase enzyme. As we?ve said before, it is aromatase that converts various drugs into their estrogenic metabolite that can bind to the estrogen receptor and bring about side effects. Arimidex is an effective anti-estrogen and had a great deal of popularity when physique athletes began to get a hold of it. The only problem was the cost. The pills came in 1mg tabs and were over $10/pill. To top it off, not many underground companies were making legitimate arimidex so you didn?t have much choice as a buyer. Now the price has dropped considerably with the availability of other anti-estrogens such as femara (a much stronger and often unnecessary anti-estrogen). Personally, companies like IP (international pharmaceuticals) have excellent products, you just need to trust your source-but that is your deal.
Okay, assuming you have access to a legit arimidex product, you do not need the full 1mg tab per day. Even if you encounter an estrogenic problem your best bet is to add a second anti-estrogen, rather than simply increasing the dosage of arimidex. No matter how cheap you can currently find arimidex, this will be a cheaper (on your wallet) and more effective technique with respect to killing the side effects. You can find cheap nolvadex and clomid almost anywhere. Just add in 20mg or so of the nolvadex or 50mg per day of the clomid (if you have a cheap connection, sometimes clomid pricing can be outrtageous too). If you have an immediate estrogen issue, pick nolvadex over clomid and start your dose closer to the 40mg per day mark. This should wipe out any estrogen currently floating around in your system and causing problems.
As for the arimidex, I (and many friends) have found .5mg every other day (eod) to be perfect. Then again, I do not particularly fall vulnerable to estrogenic side effects. If you are like me and don?t tend to get much estrogen build up, this dose will probably work fine. I have read literature (by gurus) that describes arimidex having a short half life on the accord of 4-8 hours. This is incorrect. If you consult any medical pharmaceutical book you will find the half life is much longer, in the area of 24-36 hours. Now, in my opinion I do not fully trust that the half life is quite that long either. However, I do know that the activity of the drug will last at least that long. The ?free? drug in the bloodstream has hours that can be debatable. However, for our purposes we only care about how long the drug can be active binding up that estrogen bad guy. Typically drugs which bind enzymes do not dissociate from them over the course of just a couple hours. The most important thing to consider here is the duration of drug action, which is on par with the half life listed in the medical and pharmaceutical texts, 24-36 hours. Due to the long half life, you could take 1mg of arimidex eod when wishing to increase the dosage. There really is no need to take it every single day unless you are using very small amounts per dose. For example, I like to be consistent every single day with what I do. I?ve tried the eod schedule as I explained above, but often would forget to take the dose on dose day. Instead, I found myself some .25mg tabs and then just took one tab every evening before bed. This worked great. If you are using another anti-estrogen, use it equal time spaces from you arimidex. The theory here is to maximize blood levels of one drug while the other is falling so you have round the clock protection.
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((( One of Vision's favorites )))
Proviron
Proviron is an oral DHT steroid compound similar to Masteron. Although it is not an ideal compound for building muscle (actually it is not good at all for this purpose), Proviron is helpful in stacks because of its unique ability to keep the body from turning testosterone into estrogen, thus giving the testosterone a better anabolic effect. This aids the bodybuilder in many ways. First, it helps reduce estrogenic side effects of other steroids water-retention, lowered sex drive, gynocomastia, etc. Also, Proviron can help boost the potency of testosterone in the body by freeing testosterone from its binding to sex hormone-binding globulin (SHBG).
Proviron is therefore best stacked with testosterone, which makes taking anti-estrogen compounds unnecessary. However, Proviron can cause high blood pressure so blood pressure medication may be required for those prone to hypertension.
Proviron? is the Schering brand name for the oral androgen mesterolone (1 methyl-dihydrotestosterone). Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen. In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level. It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen.
Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes. This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously. In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen. It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex (though less profound), the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues. The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia. Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced.
The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron (2methyl-dihydrotestosterone) for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect. It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.
This drug is also favored by many during contest preparations, when a lower estrogen/high androgen level is particularly sought after. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Women in particular find a single 25mg tablet will efficiently shift the androgen/estrogen ratio, and can have a great impact on the physique. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily. For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat (especially in female trouble areas like the hips and thighs).
The typical dosage for men is one to four 25 mg per tablets per day. This is a sufficient amount to prevent gynecomastia, the drug is often used throughout the entire cycle. As mentioned earlier, it is often combined with Nolvadex (tamoxifen citrate) or Clomid (clomiphene citrate) when heavily estrogenic steroids are being taken (Dianabol, testosterone etc.). Administering 50mg of Proviron and 20mg Nolvadex daily has proven extremely effective in such instances, and it is quite uncommon for higher dosages to be required. And just as we discussed for women, the androgenic nature of this compound is greatly welcome during contest preparation. Here again Proviron should noticeably benefit the hardness and density of the muscle, while at the same time increasing the tendency to burn off a greater amount of body fat. Proviron is usually well tolerated and side effects (men) are rare with dosages under 100 mg per day. Above this, one may develop an excessively high androgen level and encounter some problems. Typical androgenic side effects include oily skin, acne, body/facial hair growth and exacerbation of a male pattern baldness condition, and may occur even with the use of a moderate dosage. With the strong effect DHT has on the reproductive system, androgenic actions may also include an extreme heightening of male libido. And as discussed earlier, Women should be careful around Proviron. It is an androgen, and as such has the potential to produce virilization symptoms quite readily. This includes, of course, a deepening of the voice, menstrual irregularities, changes in skin texture and clitoral enlargement.
Proviron is also not a c17 alpha alkylated compound, an alteration commonly used with oral anabolic/androgenic steroids. Not using this structure in the case of Proviron removes the notable risk of liver toxicity we normally associate with oral drugs. It is therefore considered a ?safe? oral, the user having no need to worry about serious complications with use. This steroid in fact utilizes the same 1-methylation we see present on Primobolan (methenolone), another well tolerated orally active compound. Alkylation at the one position also slows metabolism of the steroid during the first pass, although much less profoundly than 17 alpha alkylation. Likewise Proviron and Primobolan are resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability of these compounds is still much lower than methylated oral steroids.
The popularity of Proviron amongst bodybuilders has been increasing in recent years. Many experienced bodybuilders have in fact come to swear by it, incorporating it effectively in most markedly estrogenic cycles. Due to high demand Proviron is now very easy to obtain on the black market. Most versions will be manufactured by Schering, and should cost about $1-$2 per 25 mg tab. This drug is packaged in both push-through strips and small glass vials, so do not let this alarm you. There is currently no need to worry about authenticity with this drug, as no counterfeits are known to exist. If money and availability does not prevent it, Arimidex, Femara, or Aromasin ares actually a much better choice than Proviron though. These drugs were designed specifically as an anti-aromatase, and works much more effectively than anything else we have available.
(SOME MORE INFO) by Vision Steroidsfax.com Rep
Please allow me to illustrate one of Provirons most pronounced effects ever, that somehow has failed to be discussed upon the masses.
Most of you that have ever took the breakfast of champions "Methandrostenolone", That's right, I'm talking about Dbol. What's the most apparent and conspicuous effects that takes place while taking Dbol? If you were about to say the "sense of well-being" than your correct. One of the most profound and desirable effects that we can have during a cycle..Now how about after a cycle? Or for longer durations? But we all know that many of us practice moderation with harsh orals,or I would hope, lol.
Well, one of the greatest characteristics about Proviron that has been shrouded and seldomly discussed is it's "Antidepressant" properties. With this being said, when it was first developed it was widely utilized in treatments for Bi-polar,OCD and Anxiety. As we know that depression is basically a chemical imbalance that comes about through the "Signaling" issues between receptors. Proviron improves the quality of the "channles" that the cells use to communicate and interact. Thus, a similar effect with Dbol where it drastically improves the sense of well being in users.
What I'm about to share is a double blind study that clearly shows undoubtedly astonishing results in the patients! An other great reason to consider this compound.
Why proviron is underestimated, the world may never know..
Thank you, Vision
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http://psycnet.apa.org/psycinfo/1985-28801-001
The effects of mesterolone, ... [Methods Find Exp Clin Pharmacol. 1984] - PubMed - NCBI
Citation
Database: PsycINFO
[ Journal Article ]
A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men.
Vogel, William; Klaiber, Edward L.; Broverman, Donald M.
Journal of Clinical Psychiatry, Vol 46(1), Jan 1985, 6-8.
Abstract
26 depressed male outpatients were randomly assigned to 14 wks of treatment with either mesterolone or amitriptyline in a double-blind parallel treatment design. Ss completed the Hamilton Rating Scale for Depression and a symptom checklist each week. Findings reveal that the drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline and did not produce hypomania or tachycardia, recognized side effects of amitriptyline. (10 ref) (PsycINFO Database Record (c) 2013 APA, all rights reserved)
Methods Find Exp Clin Pharmacol. 1984 Jun;6(6):331-7.
The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study).
Itil TM, Michael ST, Shapiro DM, Itil KZ.
Abstract
Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted. In a double-blind placebo controlled study, the clinical effects of 300-450 mg daily mesterolone were investigated in 52 relatively young (age range 26-53 years, mean 42.7 years) male depressed outpatients. During 6 weeks of mesterolone treatment, there was a significant improvement of depressive symptomatology. However, since an improvement was also established during the placebo treatment, no statistically appreciable difference in the therapeutic effects of mesterolone was established compared to placebo. Mesterolone treatment significantly decreased both plasma testosterone and protein bound testosterone levels. Patients with high testosterone levels prior to treatment seem to have had more benefit from mesterolone treatment than patients with low testosterone levels. The degree of improvement weakly correlated to the decrease of testosterone levels during mesterolone treatment.
PMID: 6431212 [PubMed - indexed for MEDLINE]
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All About Estrogen
Guys-Keep Your Libido, Your Brain, Your Bone, and Your Gains! Estrogen needs to be optimized and controlled precisely, not wiped out completely.
Estrogen is a great hormone. Without it, we obviously wouldn't have women-hehe. In all seriousness, there is much more to estrogen than most bodybuilders and physique atheletes think. For example, maybe you didn't know that there are three main types of estrogen that get metabolized in both the male and female body: estrone (E1), estradiol (E2), estriol (E3).
We can actually control the metabolism of these three "metabolites". Androstenedione is converted by aromatase to estrone. Estriol is converted from estrone if your nutrients are sufficient in your body. Testosterone itself is converted by aromatase to estradiol. Estradiol is by far the strongest of all three metabolites and responsible for the majority of the known effects of estrogen. Estrone and estradiol can metabolize back and forth depending on the enzymes available. So why should you care? Well, if estradiol is the strongest and most responsible estrogen, it would make sense to learn that we can control its metabolism, wouldn't it?
Separate from anti-estrogens and anti-armomatases, you can control the activity of the potent estradiol and its metabolites in your body. This is where your liver health is key. Ever get tons of water retention while on a cycle heavily based on orals? This could have very likely been due to a stressed liver not having the necessary "methylation" or "detox" ability to get rid of the potent estrogens and allow them to be excreted and metabolized without harm.
Supplements For Estrogen Metabolism
We've already mentioned that there are three main forms of estrogen: estrone, estradiol and estriol. Recall that estradiol is the most potent form of estrogen and the one that we would like to limit from excess production and activity. Of the three estrogens, estriol is the weakest.
Estrone is the form that we want to control as far as metabolism. The reason why is due to the fact that there are three further forms of "estrogen metabolites" that are made from estrone. They are 2 hydroxyestrone (2OH), 4 hydroxyestrone (4OH) and 16 alpha hydroxy estrone (16aOH). This is a complex biochemical issue but all we need to understand from our physique and health standpoint is how to limit the 4OH estrone and the 16aOH estrone. The 2OH estrone is benign in the body and is not linked with diseases like cancer and metastases.
The 16aOH estrone is mutagenic (can alter DNA unvavorably), but we can further its metabolism and excretion into a benign substance by supplying enough b-vitamins and "methyl donors". These methyl donors are nutrients that we can increase through supplementation which allow the 16aOH estrone to become the benign forms at a much higher rate and percentage. You see if we ingest enough of these "methyl donors" we push the metabolism of the 16aOH estrone further to the good "estriol" (E3).
The 4OH is carcinogenic in the breast (male and female breast) and mutagenic as is the 16aOH estrone. The great thing here is that although this sounds complex, we once again need to SIMPLY ingest more "methyl donors" and antioxidants into our diet. When we do this, the "methylated" form of 4OH becomes 4-methoxyestrone and is benign once again.
So the two bad guys are the metabolites 4OH estrone, and 16aOH estrone...both derived from the original estrone (E1). Methylators allow the metabolism of both of these mutagenic and carcinogenic substances to their benign end-point and then excreted from the body.
So what are these methylators? Here they are:
1. Vitamin B6 (pyridoxine)
2. Vitamin B12 (cyanocobalamin)
3. SAMe (s-adenosylmethionine)
4. Folic Acid
5. Vitamin B5 (pantothenic acid)
6. Indole-3-carbinol (I3C)
There are a few others, but these are great to start with. They can all be found at your nearest pharmacy, drugstore, or nutritional outlet such as
Bottom line adavantages to supplying these methylators: reduced cancer risk, reduced breast cancer risk (male and female), reduced prostate cancer risk, and less water and bloat on your physique. Pretty good return for a few dollars of extra supplements per month.