2014-09-10

Introduction

Ergota (Ergot or Argot, Fr., a cock’s spur); Ergot of rye; Spurred rye; Secale clavatum; Mater secalis; Seigle ergote (Fr.); Mutterkorn; Kornmutter (G).

Generalities

Many sharp, shifting pains in different parts of body, and stiffness of back and neck as though muscles were swollen close to occiput.

Cases

1. Mrs. L. M. Hayes, with the 200th. This prover knew the potency but not the drug. She was perfectly convinced that in the 200th potency no drug was capable of producing medicinal symptoms on the healthy, and persisted in repeating her experiments to verify or disprove former results. Took November 4th, six drops every other day for a week. November 17th, took six drops twice a day for a week. January 5th, took fifteen drops every day for a week. March 1st, took fifteen drops every morning for three days.

2. Miss. R. C. Wilder, took six drops, 30th potency, in morning of November 5th, 8th, 12th, 15th.

3. H. B. Reynolds, took one drachm of 2D potency, in repeated doses.

4. J. S. Campbell, took several doses of 2D potency.

5. F. W. Rogers, took one drachm of 200th potency, a dose twice a day for two weeks.

7. D. M. Finley, 100th potency; repeated the proving four times with same results each time.

8. Miss. H. M. Swathel, took 200th potency, from March 1st to April 23s, two or three times a day. Took 100th potency from May 2D to May 15th once or twice daily.

9. G. D. Green, took 2D potency for two weeks.

10. C. S. Erswell, took 100th potency, one drachm, in daily doses for two weeks.

11. E. H. Pond, took 30th potency.

12. E. C. Watts, took 30th potency daily for a week.

Since March, 1880, the drug was given out to seventy-two volunteers, as follows: Second potency to 16 provers.

Third potency to 4 provers.

Sixth potency to 17 provers.

Thirtieth potency to 13 provers.

Sixtieth potency to 5 provers.

One hundredth potency to 6 provers.

Two hundredth potency to 8 provers.

Blanks potency to 3 provers.

The blanks were given to those whose health, on examination, was not deemed sufficiently good to warrant a reliable proving, only one of whom (a young man who afterwards died of albuminuria) obtained or returned any results.

RULES OBSERVED.

So far as possible, every prover was examined as to health and personal qualifications; and questioned or cross-questioned on the recorded results.

Provers were directed to follow the rules laid down by Dunham for proving a drug.

No person knew what she or he was taking.

BOTANY.

Adam Lonicer, of Frankfurt, about the middle of the 16th century, is the first botanical writer to notice Ergot, and soon after Thalius speaks of it as used “ad sistendum sanguinem.”

In 1623, Caspar Bauhin mentions it under the name of Secale Luxurians, and in 1693 the English botanist Ray alludes to its medicinal properties.

The true nature of Ergot, whether a product of diseased vegetable life or true vegetable itself, has long been a source of a great diversity of opinion. But according to the latest authorities, Secale cornutum belongs to the order Thallophyta cellular or non-vascular plants. This is the lowest order of the vegetable kingdom and is divided into two classes, Algae and Fungi, which is based upon the presence in the former of Chlorophyll, and its absence in the latter. They produce no differentiation of root, stem or leaf. In the lowest members of the group there is no sexual reproduction; in the higher the sexual union may be by a single spore, or a mass of spores, or a fructification within which spores are found. De Candolle and Fries in 1816, and Leveille, in 1827, added, by their researches, much to our knowledge of the intimate structure of Secale, but it remained to L. R. Tulsane, in 1853, by his admirable monograph “Memoire sur 1′ Ergot des Glumacees,” to clear up many disputed o7 3 points in the formation, growth and development of this fungus, and this monograph is still referred to by nearly every author as the best work on the subject. Yet Fluckiger and Hanbury maintain that the true nature of Ergot has not been settled even by Tulsane’s long continued and admirable researches.

FORMATION.

Hamilton sums up the conflicting views entertained by various writers as follows: a. “Some regard Ergot as a fungus growing between the glumes of grasses, in the place of the ovary (hence Leveille calls it Spacelia segetum). b. “Some regard Ergot as a diseased condition of the ovary or seed. c. “Some have supposed that ordinary morbific causes (such as moisture combined with warmth ) were sufficient to give rise to this diseased condition of the grain. d. “Some have ascribed the disease to the attack of insects or other animals. e. “Some, dissatisfied with the previously assigned causes of the disease, have been content with declaring Ergot to be a disease, but without specifying the circumstances which induce it.”

Fluckiger and Hanbury state, “That the tissue of the seed of the rye, in the process of development, does not undergo a transformation, but is simply destroyed.

Neither in external form, nor in anatomical structure, does Ergot exhibit any resemblance to a seed, although its development takes place between the flowering time and that at which the rye begins to ripen. It has been regarded a complete fungus, and as such was named by De Candolle Sclerotium Clavus, and by Fries Spermoedia Clavius. No further change occurs in the Ergot while it remains in the ear, but laid on damp earth, interesting phenomena take place. At certain points small, orbicular patches of the rind fold themselves back, and gradually throw out little white heads.

These increase in size while the outer layers of the neighboring tissue gradually lose their firmness and become soft and rather granular, at the same time the cells, of which they are made up, become empty and extended. In the interior of Ergot, the cells retain their oil drops unaltered. The heads assume a grayish yellow color, changing to purple, and finally after some weeks stretch themselves towards the light on slender, shining stalks, of a pale, violet color. The stalks often attain an inch in length with a thickness of about half a line. Fluckiger further says: “Ergot of rye collected by myself in August, placed upon earth in a garden pot and left in the open air unprotected through the winter, began to develop the Claviceps on the 20th of March.”

Hering calls it an undetermined fungus, and from the doubtful position it has so long held in the world of science classes it, not without some reason, as a “Nosode, ” and when a doubtful point in Materia Medica is to be solved, the opinion of the venerated and scientific Hering is deserving of some consideration.

Nosode, he says: “Is the general term given to the alcoholic extracts of morbid productions, foolishly called isopathic remedies. The most useful and fully proved are Hydrophobinum and Psorinum. To these ‘Nosodes’ belong the Ustilago maidis, the Secale cornutum, the fungus of the potato, the ambra of the pot fish, anthracin, vaccinin, variolin, etc. The sneering remarks of Trinks and others in 1826 against Sepia and the ignorant opposition to Lachesis have sunken into oblivion during the succeeding score of years. All the condemning remarks against the Hydrophobinum Psorinum and other ‘Nosodes’ will meet the same fate. We can afford to wait.”

PREPARATION.

For homoeopathic use the Ergot of rye should always be prepared fresh, as it is fed on by a small acarus which destroys the interior of the grain, leaving it a mere shell. Ergot kept in stock longer than a year should always be rejected on this account.

MEDICAL HISTORY.

Among the writings of the ancients there is no distinct notice to be found of Ergot. In 1089 the French historian Singebert, refers to an epidemic in the following passage. “A pestilent year, especially in the western parts of Lorraine, where many persons became putrid, in consequence of their inward parts being consumed by St. Anthony’s fire. Their limbs were rotten and became black like coal. They either perished miserably or, deprived of their putrid hands and feet, were reserved for a more miserable life. Moreover, many cripples were afflicted with contraction of the Sinews”.

An epidermic disease in Hessia in 1596 first attracted the attention of the medical profession to Ergot as a cause. Rathlaw, a Dutch accoucher, employed it in 1747, but it was not until thirty years later, 1777, that the essays of Desgranges, and especially those of Stearns and Prescott in the United States, that its medicinal properties became known.

To the use of rye flour, more or less adulterated with Ergot, is attributed the formidable disease known in modern medicine as Ergotism, but in early times by a number of names: Morbus spasmodicus, Convulsivus Malignus, Epidemicus vel Cerealis, Convulsion Raphania, Ignus Sancti Antonia. There is now little doubt that the terrible epidemics which occurred in France in the tenth century and in Spain in the twelfth century were due to Ergot. Fluckiger and Hanbury says: “In the year 1596 Hessia and the adjoining regions were ravaged by a frightful pestilence, which the medical faculty of Marburg attributed to the presence of Ergot in the cereals consumed by the population. The same disease appeared in France in 1630 in Voightland, Saxony, in the years 1648. 1649 and 1675; again in various parts of France in 1650, 1670 and 1674. Freiburg and vicinity were visited by the same malady in 1702; other parts of Switzerland in 1715-16; Saxony and Lusatia in 1716; many other districts of Germany in 1717, 1722,1736 and 1741-42. The last European epidemic occurred after the rainy season of 1816 in Lorraine and Burgundy, and proved very fatal among the poorer classes.”

From time to time a number of monographs giving a more or less accurate description of the various epidemics supposed to have been caused chiefly by Ergot and other adulterations in France, Germany and Switzerland have appeared. In 1825, the year previous to his departure for South America Hering made a collection of these monographs which he left with Trinks, who had it completed by one of his assistants and published. These comprise the first 80 of the 170 authorities of the encyclopedias, taken from Hartlaub and Trinks. The later additions are chiefly toxicological and clinical.

Dr. R. B. Johnstone, of Pittsford, N. Y. writes. “In 1883- 84, during the building of the West Shore Railroad, I was called upon to treat many of the Italian employees for an eruption which appeared upon the body in many places, but usually on the shoulders, neck and inner surface of the upper arms. In the majority of cases it was on the right side alone, but if on both sides was always worse on the right. The eruption would begin in a small point, like the prick of a pin, which would soon assume a pimple-like form and finally become pustular and as large as a small pea. At other times they would appear as large as a small boil (half an inch across the base), of a dark bluish hue, shading off to the healthy color of the skin an inch or more from center of boil. They were intensely painful to touch, aching, burning and itching, better from light rubbing, worse from scratching, worse from heat. The small ones would dry up leaving no cicatrix, but the large ones would fill slowly with a bright yellow pus-like material, or at times a bloody, watery serum, remaining open for days, having extremely painful edges, and base, and discharging towards its close a thick, dirty, offensive serum. They were decidedly indolent in character, and left a prominent cicatrix. Cool air blowing over the eruption would relieve the itching and burning, but not the pain. Secale, Lachesis, Causticum were the remedies chiefly indicated. Having learned that the Italians ate largely of rye bread made of a very poor and cheap quality of flour, while other nationalities (not eating the rye bread) did not suffer from it at all, I attributed the eruption to poisoning by Ergot in the bread; and if a patient presented without an interpreter I usually gave Secale, which would cure about seven cases in ten.” “H. G. K. – A miller of Pittsford, N. Y., informs me that he is unable to grind rye even for a short time. Upon entering a rye mill, had a sensation of constriction in the throat, great difficulty in breathing, difficult inspiration; expiration accompanied by soreness all over the chest, oppression of the chest, soreness of the chest, intercostal pains, pricking of the tongue. “The foregoing symptoms are distinctively of rye grinding; when grinding wheat no symptoms follow. He also informs me that in two rye mills in Rochester he knows a number of individuals engaged therein who suffer as above with the addition of an eruption particularly on the neck, chest, behind the ears and around the waist. The eruption is pustular, itching violently, and discharges a yellow matter. One man he knew who was compelled to give up rye grinding because of the many boils and carbuncles. He recovered entirely after changing his occupation. Nearly all rye grinders have enlarged finger joints and poor teeth.”

DAY BOOK OF MRS. M. F. HATHAWAY.

March 6, 1885 – Took a powder (Secale 200) every morning and at night on retiring, for three days, then at night only, for a week.

March 9th. – A sore spot felt on back part of base of tongue, left side as though a “canker sore” were making its appearance; it was not felt in day time and passed away after a few days.

March 10th and 11th. – A slight frontal headache and some mental confusion, but not very troublesome. Sore spot on base of tongue, right side.

March 13th. – Spots with a sore bruised feeling appeared about and below the left knee. On looking found a swollen patch about the size of a silver half dollar, of a purple red color. Towards evening three or four similar spots appeared further down the leg, about the top of the shoe, so sore could scarcely bear the touch of the shoe, and attended with a violent itching, but were so extremely sore could not scratch them, and when touched gave a faint, sick feeling.

March 14th. – Headache and confusion more pronounced, and chiefly in frontal region. Three or four spots appeared on right leg below the knee, with violent itching and the same sore bruised feeling.

March 15th. – An eruption in the form of a rash or small pustules appeared on the face, left side chiefly, very sore and sensitive to touch. It would begin in fine points like the prick of a pin or the sting of an insect and gradually increasing in size to a small pustule as large as a pea. Felt like the spots on the legs, with the same sore, bruised feeling in the skin of face and neck. There were twenty-eight small pustules on left side of face and neck.

March 18th. – The eruption appeared on the left shoulder, several small pustules in a cluster, with the same characteristic soreness. Ceased taking drug. Dull, heavy headache in forehead and eyes; much throbbing.

Before the menses (four or five days) a dark colored leucorrhea was observed, not very profuse, but attended with a tired and uneasy feeling in the pelvis.

April 5th. – The eruption on face, neck and shoulders gradually disappeared, but left discolored, ecchymosed spots and patches like the remains of an old bruises for several weeks, especially on lower leg. April 18th. – Menses appeared on time very profuse for the first three or four days, accompanied by a good deal of pain and an uneasy sore feeling through the pelvis (much more than usual), but an unusual amount of pain for a week before the menses. Flow darker, much more profuse (formerly profuse for one day) for four days. Considerable clotting. The flow continued for ten days, a circumstance which never occurred before. Vertigo during entire menstrual period, with inclination to fall forwards.

Was attacked while at lectures with palpitation which continued nearly all the afternoon. Could feel the heart flutter and remit. Pulse 108 and 110. Violent throbbing of the carotids, faint for several hours. Never had palpitation before in her life.

Headache; full, throbbing, bursting, like a Glonoine headache (has proved Glonoine), only not so sore on shaking the head.

Characteristics

Adapted to women of thin, scrawny, feeble, cachetic appearance, irritable, nervous temperament; pale, sunken countenance.

Very old, decrepit, feeble persons.

Women of very lax muscular fibre; everything seems loose and open; no action, vessels flabby; passive hemorrhages, copious flow of thin, black, watery blood, the corpuscles are destroyed.

Hemorrhagic diathesis; the slightest wound causes bleeding for weeks (Lach., Phos.); discharge of sanious liquid blood with a strong tendency to putrescence, tingling in the limbs and great debility, especially when the weakness is not caused by previous loss of fluids.

Leucorrhea: green, brown, offensive.

Boils: small, painful with green contents, mature very slowly and heal in the same manner; very debilitating.

Face: pale, pinched, ashy, sunken, hippocratic, drawn, with sunken eyes; blue rings around eyes.

Unnatural, ravenous appetite; even with exhausting diarrhea; craves acids, lemonade.

Diarrhea: profuse, watery, putrid, brown; discharged with great force (Gamb., Crot.); very exhausting; painless, involuntary, anus wide open (Apis, Phos).

Enuresis: of old people; urine pale, watery, or bloody; urine suppressed.

Burning in all parts of the body, as if sparks of fire were falling on the patient (Ars.).

Gangrene; dry, senile, agg. from external heat.

Large ecchymoses; blood blisters; often commencement of gangrene.

Collapse in cholera diseases; skin cold, yet cannot bear to be covered (Camph.).

The skin feels cold to the touch, yet the patient cannot tolerate covering; icy coldness of extremities.

Menses: irregular; copious, dark fluid; with pressing, labor like pains in abdomen; continuous discharge of watery blood until next period.

Threatened abortion especially at third month (Sab.); prolonged, bearing down, forcing pains.

During labor: pains irregular; too weak; feeble or ceasing; everything seems loose and open but no expulsive action; fainting.

After pains: too long; too painful; hour-glass contraction.

Suppression of milk: in thin, scrawny, exhausted women; the breasts do not properly fill.

Pulse small, rapid, contracted and often intermittent.

Mind

Stupid, half-sleepy state.

Impaired power of thinking.

Delirium: quiet, wandering.

Mania: with inclination to bite, with inclination to drown.

Uncomfortableness and depression.

Fear of death.

Anxiety, sadness, melancholy.

Great anguish, wild with anxiety.

Apathy, indifference.

Constant moaning and fear of death.

Great anxiety and difficult respiration.

Excessive sadness, gradually changes to cheerfulness, talks and acts foolishly, rage, followed by continuously deep sleep.

Paralytic mental diseases; treats his relations contemptuously and sarcastically; wandering talk and hallucinations; apathy and complete disappearance of the senses.

Laughs, claps her hands over her head, seems beside herself.

After miscarriage.

Memory failed. Forgot names of friends whom I met daily.

Confusion of mind. Unpleasant forebodings.

Anticipated misfortunes, as though about to lose something of great value.

Sensation of intoxication while undressing, to retire (third day and for several successive evenings).

During the entire proving I experienced an elevation of spirits, felt buoyant and exhilarated.

Sensorium

Unconsciousness, with heavy sleep, preceded by tingling in head and limbs.

Diminution and loss of senses, sight, hearing etc., All the senses benumbed.

Consciousness seems to continue until the last breath, and just before death it seems as if patient would improve.

Stupefaction; stupor.

Vertigo: constantly increasing; with stupefaction and heaviness of head, reeling, inability to stand erect, peculiar feeling of lightness of head, particularly in occiput, as from intoxication, unsteady gait.

Heaviness of head and tingling in legs.

Sensation of intoxication while undressing.

Inner Head

Pulsations in head with giddiness, she cannot walk.

Pain and confusion most in occiput.

Congestion to head and chest.

Headache; hemicrania on left side.

Vertigo during entire last menstrual period, inclination to fall forwards.

Head heavy. Sharp stinging pain running upwards through the left eye into forehead and left side of head; coming in paroxysms.

A dull heavy, at times pressing headache, most severe on right side, aggravated in warm room, but not ameliorated in open air.

Dull pain on each side of the head, above and before the ears, worse in warm room. At times it was throbbing, and continued with more or less severity for three weeks after leaving off the drug.

It was semi-lateral at times, and seemed to prefer the right side and forehead.

Feels oppressed; stupid, heavy, aches every night, would waken me at night, ameliorated by eating breakfast and exercise.

Could not sleep on account of the fearful oppressive headache, extending from occiput up over head to the eyes.

Severe pain in occiput, forehead, temples, back of eyes aggravated by pressure on nape of neck.

Headache aggravated in open air, and first entering warm room, as after riding in cold north wind in winter, when entering warm room the head aches so fearfully.

More or less, a dull headache during the entire proving, especially in the forehead and eyes.

Head full, throbbing, bursting, like a Glonoine headache, though not so sore on shaking the head.

Continuous, supra-orbital headache (developed after proving the remedy a week.) Pain from forehead to the eyes; burning sensation in the eyes, no inflammation; pain shoots through the eyeball backward.

Outer Head

Hair falls out.

Twisting of head to and fro.

Scalp sore.

Scalp sore; so painful, cannot bear to move the hair.

Felt as though the hair had been parted in a new place, or pressed by hair pin.

Hair looked at roots as though bulbs were enlarged.

Scalp slightly pink in irregular spots; pimples appeared over scalp; small, very sore to touch, with slight burning sensation.

Eyes

Photophobia.

Dimness of vision; mistiness before eyes. Cataract.

Double or triple vision.

Blue and fiery dots flying before eyes.

Pain in eyes with feeling as if they were spasmodically rotated.

Stitching pain in eyes; pressure on balls.

After an epidemic of the rye disease an unusually large number of cataracts occurred in young people, twenty-three of whom gradually became blind (fifteen men and eight women), associated with headache, vertigo and roaring in ears; of the cataracts two were hard, twelve soft, and nine mixed.

Cataracta senilis.

Suppuration of cornea; agg. from warm application.

Retinitis diabetica.

Dilation of pupils.

Suppressed secretion of tears.

Injection of conjunctiva.

Eyes sunken, surrounded by a blue margin.

Paralysis of the upper lids, from coal gas.

Immovable state of eyelids after facial erysipelas.

Eyes look fixed, wild, glazed; staring look.

Pustulous conjunctivitis and blepharitis.

Exophthalmos with struma.

Exophthalmic goitre.

Ears

Undue sensitiveness of hearing, even slightest sound re-echoed in her head and made her shudder.

Confused hearing; deafness. After chorea.

Singing in ears and difficult hearing.

Humming and roaring in ears, with occasional deafness.

Nose

Sneezing.

Nose feels stopped up, yet watery discharge runs from it.

Nose stopped up on left side as with a solid plug.

Nosebleed: blood dark, runs continuously, with great prostration, small, threadlike pulse, in old people or drunkards; of young women; from debility.

Passive morning epistaxis from left side, bright red.

Morning nose-bleed, something very unusual; left side only, passive, but bright red.

Nose stopped up on left side as with a solid plug, but not much discharge.

Nose sore to touch externally and internally.

Nose-bleed not very profuse, recurring for several successive days.

Bleeding at the nose on every attempt to wipe it.

Face

Face: pinched, pale, earthy-looking; sunken, hippocratic, ashy; swollen; contracted, discolored, with sunken eyes blue rings around eyes; risus sardonicus; distorted; wan, anxious.

Tingling in face.

Muscular twitchings usually commence in face and then spread all over body, sometimes increasing to dancing and jumping.

Spasmodic distortion of mouth and lips.

Forehead hot.

Lockjaw.

Lips deathly pale or bluish.

Oppressed, full of blood during fever.

Face and neck feel hot, as if full of blood and ready to burst.

Mouth

Bloody or yellowish green foam at mouth.

Increased secretion of saliva; ptyalism.

Much acid fluid in mouth.

Spitting of blood.

Fetid breath.

Speech difficult, slow and weak with a feeling at every motion as if there was some resistance to be overcome.

Dryness of mouth.

Dry, but seldom thirsty. Burning dry sensation, not relieved by drinking. Brackish taste.

Stammers unintelligible words between teeth; speech difficult and stammering; speech slow and weak, with a feeling on every motion as if there were always some resistance to be overcome.

Throat

Dryness of soft palate, throat an esophagus, with thirst.

Burning in throat with violent thirst.

Painful tingling in throat and on tongue.

Throat sore on left side running up into ear.

Follicular pharyngitis; hawking up of little follicular exudates.

Diphtheria: loss of strength; rapid loss of sensibility; numbness of extremities; painful tingling and crawling on tongue; dry gangrene; apathy; dilated pupils; burning pains of affected parts; stammering speech; absence of all reaction.

Severely paralyzed both in swallowing and in speaking; could scarcely take food without great danger of choking; speech reduced to a whisper; could not bear heat or covering and would throw all covering off. Post-diphtheritic paralysis.

Soreness with dryness and sensation of constriction, better by swallowing; symptoms worse mornings.

Rawness, dryness and constriction of throat, without any pain.

Throat sore on left side running up into ear.

Throat on right side red, sore, with a feeling as if it were constructed of tense and hard fibres, very slightly hoarse.

Later throat felt constricted, chiefly on right side; right side and back of throat inflamed, red and “stiff” some pain on swallowing. (I am not inclined to right sided sore throat, almost all my attacks of the kind being confined to the left side.).

Stomach

Tenderness of epigastrium.

Anxiety and pressure in pit of stomach, with great sensitiveness to touch.

Severe anxiety and burning at pit of stomach.

Pain in pit of stomach.

Violent pressure in stomach, as from a heavy weight.

Warmth and feeling or repletion.

Burning in stomach.

Painful constriction of epigastrium.

Great distress and oppression of stomach.

Bilious vomiting, with cramping pains in stomach, burning in stomach extending up esophagus; head sunk upon breast, face pale, yellowish, voice weak, pulse small. Cardialgia.

Attacks of severe pressure and constriction in region of stomach extending through to spine, extremely painful and followed in half an hour by vomiting of tasteless fluid or of contents of stomach, thereupon an intermission of several hours occurred; during attack region of stomach felt as if contracted, and on percussion gave a tympanitic note, has three to four attacks daily.

Hemorrhage from stomach; lies still with great weakness but no pain; face, lips, tongue and hands deadly pale, skin covered with cold sweat, pulse frequent, threadlike; oppression; abdomen soft, without pain. Hematemesis.

Hematemesis; attacks preceded by pains in epigastrium and nausea, pain going to left side when pressure is made in epigastrium, marked protrusion in left hypochondrium, with pain, blood red, never containing particles of food, and when collected in basin appears more like bloody serum than pure blood and is of offensive odor, quantity vomited not very large; frequent chilliness at night, followed by profuse sweat; strength not much impaired; appetite and sleep good.

Eructations: having the odor of burnt horn.

Appetite much increased; was very hungry, ashamed to eat as much as desired.

Felt as though I had dined on chopped cabbage.

Nausea after leaving table.

Felt too full, fermented; much flatulence. Flatulence rumbling through stomach and bowels.

A tired sensation-one of distress and oppression-over region below the stomach, was present much of the time during the proving.

Appetite

Ravenous, insatiable appetite, even when dying from exhausting discharges from bowels.

Hunger as from long fasting.

Disgust for food, especially for meat and fatty things.

Thirst: during all stages of fever, unquenchable; for acids.

Great thirst and dryness of mouth and throat, with burning and tingling of tongue.

Desire for: sour things; lemonade.

Hiccough, belching, nausea and Vomiting

Eructations: with disagreeable taste; sour, tasteless but with subjective disagreeable, empyreumatic odor; empty.

Nausea: inclination to vomit; painful retchings; constant, agg. after eating.

Excessive nausea and debility, with very little vomiting of a dark brown coffee-grounds fluid.

Vomiting: of food, of bile; of mucus, of green, offensive, watery fluid, painless and without effort, with great weakness, immediately after eating, of lumbrici; of blood; black vomit.

Hematemesis, patient lies still; great weakness but no pain; abdomen soft.

Abdomen

Distension of abdomen, tympanites; meteorism.

Flatulence with rumbling.

Painful sensitiveness and rumbling, with continual nausea and confusion of head.

Inclination to colic, diarrhoea, and bloated abdomen.

Pain in lower belly, preventing and upright position, even forcing him to lie doubled up in bed.

Colic with convulsions.

Pain in abdomen with burning in stomach.

Pain in hypogastric region.

Pain in loins as from false labor pains.

Continual bearing down in lower abdomen.

Burning in abdomen.

Cold feeling in abdomen and back.

Strong pulsation in umbilical region.

Lumps and welts in abdomen, in affection of uterus.

Aneurism of mesenteric artery, in women.

Abdomen much distended.

Distension of abdomen; much flatulence as though soon to suffer from diarrhoea.

Spasmodic jerking of small intestines near sigmoid flexure as though tied about with strings, which were interruptedly pulled.

Worse evening, and better by pressure and lying on affected side.

This lasted for about three weeks.

Bowels felt weak, sick, faint, as in summer from eating too much fruit, no pain but hot and dry internally.

Bowels did not pain, and seemingly would have been relieved of heat, dryness and uncomfortable feeling if I could have drunk water enough to reach them, which I was unable to do. Neither drinking water nor an enema gave relief.

Hypochondria

Enlargement of the liver.

Inflammation and gangrene of liver; acute pains in hepatic region; tongue thickly coated with a brown tenacious substance, burning in throat, unquenchable thirst, great weakness, but no pain; limbs cold and covered with cold sweat.

Burning in spleen; thrombosis of abdominal vessels.

Stool

Diarrhoea: very exhausting; pernicious; very offensive; involuntary, profuse, watery, putrid, brown, discharged with great force; very exhausting; urine suppressed; painful with great prostration; painless with tingling and numbness in limbs; putrid, fetid, colliquative, patient does not want to be covered or to be near the heat, but prefers to be in the air or wishes to be fanned, sudden attacks; of children, discharges whitish, watery; chronic in over fed children, great prostration; during August; great stools undigested, or watery, at times yellowish, also greenish, with forcible expulsion, accompanied by discharge of flatus; paralytic weakness of sphincter ani with involuntary discharges.

Stools: yellowish; greenish; brownish; watery and flocculent; colorless, watery; profuse; frequent; putrid; gushing; involuntary; watery, slimy; thin, olive green; offensive, watery; fetid, dark colored; thin, involuntary; watery, yellowish or greenish, discharged rapidly with great force and even involuntarily; painless, without effort and with great weakness.

Before stool; cutting and rumbling in abdomen.

During stool: cutting great exhaustion; coldness.

After stool: exhaustion.

Five to ten minutes after taking least quantity of food, severe colic which made her bend double and cry out; pain begins between region of stomach and navel, extends thence to sides and rest of abdomen and down to sacral region, accompanied by severe urging and tenesmus, followed by a thin, slimy, yellowish stool with some relief of pain; four to five such attacks follow each other; then relief until she eats again, four or five evacuations during night; she compares pains to labor pains; great thirst; thick mucous coating on tongue, sleep disturbed; prostration. Diarrhoea.

Uncomfortable fullness of abdomen, with transient pinching pains in upper abdomen as from flatus; at night severe cutting pains throughout whole abdomen; restless anxious tossing about, with short and unrefreshing naps, during night anus firmly closed, “as if locked up;” in morning frequent short watery evacuation, in gushes, preceded by cutting pains in abdomen.

Stools yellowish-white, slimy, undigested, escaping involuntarily, agg. at break of day. Diarrhoea.

Interminable diarrhoea in summer, which resists everything, especially in scrofulous children, putrid, fetid and colliquative; choleraic symptoms, with cold, clammy perspiration; sinking spells at 3 A.M. (not the restless anguish of Arsenicum).

Colliquative diarrhoea.

Cholerine with more retching than vomiting.

Cholera infantum; profuse undigested stools, watery and very offensive, discharged by fits and starts and followed by intense prostration; pale face, sunken eyes, dry heat, quick pulse, restlessness and sleeplessness; great aversion to heat and to being covered. Cholera infantum.

Vertigo, cramps or drawing in calves of legs, rumbling in abdomen, nausea, stools in rapid succession, brownish or colorless, rapid prostration, coldness of limbs, tongue but slightly coated.

Profuse prostrating evacuations severe painful cramps in feet, toes, hands and fingers which are spread apart or extended towards back of hands; cramping pressure in stomach; dry, wrinkled, cold skin; cyanotic color. Cholera.

Cholera infantum; cholera morbus; cholera Asiatica.

Patient cold, almost pulseless, with spasmodic twitching of muscles in various parts of body, spreads finger asunder; eyes sunken, features pinched; much spasmodic retching although not much vomiting; skin harsh, shrivelled, dry, as if there were no moisture left in system; urine suppressed; tingling or formication all over body; stools profuse, watery, ejected with great violence; is cold but cannot bear to be covered. Cholera.

Aversion to heat or being covered, with icy coldness of extremities.

Diarrhoea after cholera.

Cholera Asiatica, with collapse, sunken, distorted face, particularly mouth, crawling sensation as from ants.

Paralysis of rectum, anus wide open.

Hemorrhage from bowels.

Constipation.

Constipated; dry, dark, detached, yet difficult to expel.

No desire for days, feels as though rectum was full.

Frequent stools; light colored, soft.

Diarrhoea: stool small, scanty. Almost every time urine was passed during the day, a small stool.

Constant desire for stool.

Urinary organs

Retention of urine; urine pale or bloody; discharge of thick black blood from kidneys; obstruction of sight. Scarlatina.

Diabetes; great general lassitude; heaviness of limbs; loss of strength; emaciation; gangrene; skin dry and withered; furuncles; petechiae, fever, with unquenchable thirst; diminished power of senses; dryness of mouth, morbidly great appetite, cardialgia; costiveness; diarrhoea, watery urine, increased quantity of urine.

Hematuria in a boy suffering from suppuration of the glands of neck after scarlet fever, urine also very albuminous; anasarca; great thirst.

Passive hemorrhage, blood thin; blood corpuscles wanting in consequence or dissolution; or painless discharge of thick black blood in consequence of kidney disease; coldness of body, cold perspiration on forehead; great weakness. Hematuria.

Urine suppressed; on introducing catheter a gill of dark, prune colored urine passed, which appeared to be full of gritty sediment emitting a very disagreeable odor.

Unsuccessful urging to urinate.

Ischuria paralytica.

Paralysis of bladder.

Enuresis: old people; pale, watery or bloody urine.

Urinary deposit looking like white cheese.

Bloody, albuminous urine.

Discharge of thick black blood from bladder; kidney affections.

Urine increased in quantity, lighter color, passed more frequently, especially at night. Milky on standing a short time.

Pressure in bladder at night.

Male Genitalia

After lightness in occiput, violent dragging in spermatic cord causing sensation as if testicle were being drawn up to inguinal ring.

After sexual excess palpitation of heart.

Weak memory after exhausting coition; impotence.

Clonic spasmodic stricture of urethra.

Female genitalia

Uterus and right ovary much congested, very sensitive to touch.

Pain in ovaries and uterus.

Pains of an expulsive character in uterus.

Prolonged bearing down and forcing pains in uterus; thin and scrawny subjects.

Burning pains in greatly distended uterus, which felt hard and was painful to touch.

Putrescence of uterus; abdomen distended, not very painful; discharge from vagina, brownish, offensive; ulcers on external genitals discolored and rapidly spreading; burning hot fever, interrupted by shaking chills, small, sometimes intermittent pulse, great anguish, pain in pit of stomach, vomiting decomposed matter; offensive diarrhoea; suppressed secretion of urine, skin covered with petechial and miliary eruptions or shows discolored, inflamed places, with a tendency to mortification, the patient lies either in quiet delirium or grows wild with great anxiety and a constant desire to get out of bed. Metritis.

Metritis; tendency to putrescence; inflammation caused by suppression of lochia or menses; discharge of thin black blood, a kind of sanies, with tingling in legs and great debility. Metritis.

Cancer and gangrene of uterus.

Uterine ulcers feel as if burnt, discharge putrid, bloody fluid.

The uterus that had previously been in a normal condition descended so that it almost protruded, was hot and painful; os open as large as middle finger; excessive desire to urinate; labor pains only relieved by wet bandages or pressure upon abdomen; lasted three days, did not miscarry though os remained open during this period, afterwards uterus gradually ascended, pains diminished, and after five or six days os contracted; went on to eighth month, when she miscarried.

Uterus about an inch from labia inferiora, membrane around it felt hard, while rest of mucous membrane of vagina was very much relaxed and gathered into a fold at lower part.

Partial prolapsus of uterus for eight months after a forceps delivery; dysuria; sense of weight over pubes as if contents of abdomen would fall forward.

Prolapsus of three months standing; frequent severe cutting pains in abdomen, occasional nausea.

Dreadful bearing down, dragging out feeling in lower abdomen, so that her life is almost unbearable, every four or five day profuse, thick, yellow discharge from vagina, hesitation in urinating, rheumatism. Hysteralgia.

Hemorrhage from uterus; apparent death of newborn child.

Incessant metrorrhagia.

Uterine hemorrhage: when uterus is engorged; with pains in sacrum, extending down thighs and pressing into lower abdomen of a pregnant woman, profuse protracted flow; tearing, cutting colic, cold extremities and cold sweat, weak, hemorrhage agg. from slightest motion, blood thin and black, black, lumpy or brown fluid, of disgusting smell, black liquid blood.

A woman, age 45, passed through a normal confinement seven years ago; miscarried about two years ago, hemorrhage kept up for five months under allopathic treatment, with exacerbation during time of menstruation; after ceasing for seven months, hemorrhage set in again with slight intermission of one or two weeks; excessive anemia; sunken features; skin cold and dry; pulse small and quick; heavily coated tongue; loss of appetite; headache; since five days, daily ten or twelve painless stools, of mucous, watery, sometimes foul-smelling masses; thin, black, foul- smelling bloody discharges.

Feeble and extremely emaciated, skin flaccid, face very pale and sunken, with an expression of suffering, mucous membranes pale and cool, hands and feet deficient of natural warmth, action of heart, quickened, breathing short and oppressed, pulse very small, 120; abdomen distended; os uteri very open, with indented and puffy edges, flaccid and soft, vagina tender and cool, manual examination caused much uneasiness and flooding; violent headache limited to one spot, throbbing in temples, roaring in ears, giddiness on slightest movement; enfeebled nervous system showed extraordinary excitability; many times in day, and especially at night, cramps in calves and spasmodic twitching of limbs, causing exhaustion, remains several hours in bed as if paralyzed; digestion and sleep disturbed to some extent; hemorrhage still continued, even in horizontal position, and elevation of pelvis caused no diminution in large quantity of blackened coagula which were constantly passing, while least movement increased discharge in a very great degree. Chronic passive hemorrhage.

Uterine hemorrhage, flow passive, dark and may be offensive, tingling or formication all over body, holds her fingers spread asunder, asks to have her limbs rubbed, finally lies unconscious and cold. Metrorrhagia; relaxed condition of body; depressed, anxious state of mind, unusual drowsiness by day, gush of thin black blood on least movement of body, general feeling of prostration; diminished temperature of body, wooden, numb feeling in lower extremities.

Uterine hemorrhage; did not wish to be covered, desired windows to be open, though room was very cold and surface of body like a corpse.

Painless flooding in feeble, cachectic, dyscratic women, or such as have long resided in tropical climates.

Since last delivery menses too seldom and very irregular, last time rather copious in consequence of unusual exertion; at night dreamed she was ascending the stairs with a heavy load, and suddenly a clot of blood came away and the blood seemed to gush forth; the alarm awakened her she found that she was bleeding fast, on following morning strength greatly reduced, lips and whole body, even tongue, deathly pale, pulse could not be distinguished, frequent fainting fits; periodic pains with expulsion of clots of blood and between these attacks constant oozing of thin bright blood.

An excessive menstrual flow every two weeks, lasting seven to nine days; for last four weeks flow is continuous, very weak and thin, has severe pains in loins and uterine region, bearing down pains as if in labor.

Menses: too profuse and lasting too long; with tearing and cutting colic, cold extremities, cold sweat, great weakness and small pulse, or with violent spasms.

Menstrual blood: thin and black, black, lumpy or brown fluid and of disgusting smell.

Menstrual colic; pains so severe as to frequently cause spasms; uterine region very sensitive to touch; high fever; pains amel. when flow appears.

Menstrual colic; pale face; coldness of limbs; cold sweat; small, suppressed pulse, tearing, cutting pains in abdomen.

Menses irregular; every four weeks for three to four days, copious dark-red fluid discharge of blood, with pressing, labor like pains in abdomen; constipation; pressure in occiput; afterwards continuous discharge of watery blood, until next period.

Suppression of menses with pain.

Gangrene of whole vaginal mucous membrane, on holding apart the labiae this membrane was found of a dark slate color, emitting the characteristic odor.

Vagina hot or cool.

Discharge from vagina almost black, fluid and very fetid.

Leucorrhea: in thin, scrawny women, with prolapsus uteri; green, brown, offensive, like cream, from weakness and venous congestion.

Ulcers on outer genitals, discolored and rapidly spreading.Sharp pains in left ovarian region, week before menses.

Menses a week too soon (always regular before to a day).

Flow bright red and coagulable; many clots.

Offensive in odor; a cold cadaverous smell.

Before the menses (four or five days) a dark colored leucorrhea was observed, not very profuse, but with a very uneasy feeling about the pelvis.

Menses appeared very profuse, lasting for ten days, but only profuse for the first three or four days, accompanied by a great deal of pain and an uneasy sore feeling (more than usual), and a dull headache during entire proving, especially in forehead and eyes.

Catamenia occurred on time. Flow easy, abundant, painless and entirely without clot.

Passed a membrane. Period ceased (fifth day), having been entirely free from discomfort.

At second period the flow was of good color, rather fluid, a few clots.

Continuous exercise stopped it on the second day, but no backache, headache or other disagreeable symptoms appeared in consequence.

Next period appeared at proper time “with few premonitory symptoms, ” but with a feeling all day as if I must keep still or have the flow checked. Passed a membrane. In four days menses ceased. (During the spring months of the past two years have passed membranes at the monthly period, but never before in consecutive months). The flow is usually attended with uneasy feelings and is always greatly clotted.

Leucorrhea the week before, discharge like white of egg (many times daily), changed just before menses to a yellowish offensive discharge, irritating; relieved by bathing parts in cold water.

After menses sharp pains in uterus and pelvic region, with dragging, bearing down sensation, and aching across small of back.

Genital organs feel as if full of hot blood, pressed to their utmost capacity. The surface did not burn, but felt as though blood-vessels were filled with hot blood.

Uterus prolapsed; region sore to touch. This condition continued for weeks.

Menses one week too soon, too profuse, and what is very unusual, attended with much bearing, pressing down pain.

Second month, four days too soon, flow darker than customary and offensive, but not clotted, lasts two days longer and is too profuse but not weakening.

Vertigo at the time of the menses with pain and heaviness in the pelvis for a week before the menses.

Unusual amount of pain and heaviness in pelvis for a week before menses.

Flow darker, much more profuse (formerly profuse for one day only) but this lasted four days.

Considerable clotting.

Pregnancy, Parturition and Lactation

Arrested development of fetus.

Discharge of blood during pregnancy.

Threatened abortion: more especially at third months; with copious flow of black, liquid; false labor pains, with bloody discharge; in feeble, cachectic women, having a wan, anxious countenance, pulse almost extinct, fear of death, convulsive movements.

Extremely violent pains, almost without intermission, she seemed to be in the last stage of labor, but on examination os was found about the size of a half dollar, thick and somewhat rigid.

Extremely violent pressing labor pains, os however, being only about as large as a ten cent piece; hysterical convulsions.

When advanced about seven and a half months in pregnancy was taken with labor pains, wriggling and not distinctly intermitting; os tincae open, and about size of a shilling, dulness and slight aching of head, despondent.

Prone to abortion in third month; had passed through five, although she kept her bed as soon as pregnant; some labor pains with bloody discharge; was able to attend to her household duties and went to full term.

After lifting a heavy weight during sixth month of pregnancy severe pains in stomach, abdomen and small of back and a pushing-down sensation, violent movements of fetus; cold feet, numbness and tingling in feet, small weak pulse.

After abortus: difficult contraction of uterus; thin, black, foul-smelling discharge.

Retained placenta, after miscarriage, especially when occurring during early months of pregnancy, offensive discharges; patient cold and often almost pulseless from loss of blood; uterine contractions very imperfect, or else prolonged tonic contraction.

During eighth month of pregnancy violent convulsions with frothing at mouth, etc., followed by variable spasms; insensibility and clonic spasms, agg. at every pain; on return of consciousness complained of dull frontal and occipital headache and incessant uterine pains. Premature labor.

During pregnancy: frequent and prolonged forcing pains, particularly in thin, ill-conditioned women, cramps, in calves.

Uterine pains prolonged but ineffectual.

A sensation of constant tonic pressure in uterine region; causes great distress, desires fresh air, does not like to be covered.

Hour glass contraction.

During labor: prolonged bearing-down and forcing pain in uterus; pains irregular; pains too weak, pains feeble, or ceasing; everything seems loose and open, no action, fainting fits.

Strength of uterus weakened by too early or perverted efforts.

Thin, scrawny women, skin shrivelled, dry and harsh, sallow face, weak in labor; pains seem to be entirely wanting; uterus flabby; bearing down in sacral region, a sort of prolonged urging feeling in abdomen.

While the head was passing in lower strait, she was suddenly seized with violent convulsions lasting about three or four minutes, followed by a stupid state with stertorous breathing and uneasy moaning as if from pain.

Labor ceases, and twitching or convulsions begin.

Puerperal convulsions with opisthotonos.

Retained placenta, with constant, strong bearing down in abdomen, or with relaxed feeling of parts.

After labor, pale, weak, uterus distended, burning pains therein, hard, painful to least touch, discharge of black, coagulated or brown, watery offensive-smelling blood; throbbing, tearing pains in thighs extending down to toes, pain agg. from motion; strong pulsation in umbilical region, which could be felt by the hand at wrist weak and rapid; frequent yawning.

Postpartum hemorrhage, with relaxation of uterus only temporarily relieved by compression; after – pains excessive, agg. when child nursed. After – pains: too long and too painful.

Violent after-pains with hemorrhage arising from irregular contractions; the longitudinal fibres alone contracting in such a manner as to leave a sulcus in middle, making it appear as if uterus were split open from top to bottom.

Cessation of lochia, with fever, inflammation of uterus, subsequently an abscess opened through vagina.

Lochia: dark, very offensive; scanty or profuse; painless or accompanied by prolonged bearing-down pain; suppressed, followed by metritis; suddenly changes character and becomes of a dirty brown or chocolate color, with fetid odor, grows sad and melancholy and fears death, of too long duration.

Fever with frequent watery stools. Puerperal fever.

Strong tendency to putrescence; discharge of sanious blood, with tingling in legs and great prostration; urine suppressed; offensive diarrhoea, voice hollow with difficult breathing, feeble and inaudible; burning fever interrupted by shaking chills, does not care to be covered; cold limbs, cold sweat over whole body, gangrene.

Suppression of milk, the milk will not flow from the breast.

Lack of milk with stinging in mammae.

In women who are much exhausted from venous hemorrhage; thin, scrawny women, the breasts do not properly fill with milk.

Thin, scrawny children with shrivelled skin, spasmodic twitching, sudden cries, feverishness.

Pendulous abdomen.

Promotes expulsion of foreign bodies from uterus.

Married woman, aged 25, had severe pain in the pelvic region, great bearing-down, excruciating rectal and vesical tenesmus; restless sleep, high fever, and heavily-coated tongue. Sub peritoneal hematocele was diagnosed in consultation. Tumor increased rapidly, and increased fever; pulse 130 to 150, tongue dry, dark brown; sordes on the teeth; vaginal secretions fetid; frequent urgent micturition; mucous dysentery, with increased tenesmus; countenance expressive of great suffering. Under Secale, tumor discharged through the rectum, large quantity of dark, thick blood, patient gradually recovered.

Respiration

Respiration: slow; labored and anxious; oppressed; moaning; constant sighing; hiccough.

Blood is sometimes expectorated during violent efforts to breathe.

Lungs during chill felt as though respiration fanned air on a perfectly dry surface; only during chills.

Sharp pains through left chest, especially when walking.

Cough

Hard, hoarse cough, with but little expectoration.

Concussive cough; profuse perspiration; sleepless nights; inclination to colic; diarrhoea; bloated abdomen; emphysema. Bronchitis.

Spitting of blood, with or without cough.

Larynx and trachea

Voice: hollow, hoarse, with difficult breathing; feeble and inaudible; weak, unintelligible, stammering.

Thickening of mucous membrane of air passages.

Lungs during chill felt as though respiration fanned air.

Inner chest

Cramp in chest.

Pains over nearly whole front part of chest, agg. from coughing and motion.

Expectoration of dark, frothy, rather viscid blood, brought up by a slight cough and amounting to a teacupful in four hours; a spot as large as a crown piece on right side of chest to right of nipple, dull on percussion, with bronchial respiration and mucous rale over that part.

Back and neck

Tumors on neck discharging yellow pus.

Gentle, creeping sensation in back, as if a soft air were blowing through it.

Tingling in back, extending to fingers and toes.

Pain in small of back.

Stitch in back.

Sudden “catch” or “kink” in back.

Pains in sacrum with bearing down as if parts would be forced out, agg. when moving.

Hard, hoarse cough, with but little expectoration; pains nearly all over front part of chest, agg. from coughing and motion; for several years tenderness of lower cervical and upper dorsal spinous processes, with stiffness of neck; agg. from every exertion or strain upon spine; pressure upon diseased portion of spine produces pain there, as well as all through chest, with irritation to cough.

Stitches in upper dorsal vertebrae (between shoulders), constant when sitting, intermittent when standing, at times extending into hands, agg. by pressure upon vertebrae; frequent formication through all limbs; at times rigidity and spasmodic stretching of fingers so that for several minutes he cannot sew; frequent pressure and swelling beneath epigastrium; pain in back agg. when sewing.

Violent pain in back, especially in sacral region; anesthesia and paralysis of limbs, convulsive jerks and shocks in paralyzed limbs; painful contraction of flexor muscles; paralysis of bladder and rectum. Myelitis.

Myelitis diffusa.

Paraplegia preceded by cramps and muscular pains.

Difficult, staggering gait; complete inability to walk, not for want of power but on account of a peculiar unfitness to perform light movements with limbs and hands: contraction of lower limbs on account of which patient staggers; trembling of limbs, sometimes attended with pains; formication of hands and feet; excessive sensation of heat, with aversion to heat or being covered.

Spine disease with gressus vaccinus.

Muscles of neck stiff, sore.

Shoulder-blades and clavicle lame, as though wrenched or twisted.

Back aches; feels weak, especially in sacrum.

Sharp, shifting pain in all parts of body.

Upper limbs

Arms fall asleep.

Rough rash all over arm.

Spasmodic jerks of hand, with flexion of hand at wrist or of forearm.

Numbness and insensibility of hands and arms.

Burning in hands.

Hands deathly pale.

Coldness and numbness of right hand with tingling of ring and little fingers.

Loss of feeling in backs of fingers.

Loss of muscular power and of feeling in hand.

Fingers convulsively drawn in toward palm, clasping thumb.

Contraction of fingers.

Fingers bent backward or spasmodically abducted.

Left thumb spasmodically drawn toward dorsum of hand, followed in a few minutes by cramping and flexure of rest of fingers toward palmar surface; hands feel numb like velvet; next day both hands became affected and after several days felt a tingling and stitches in legs, followed by heaviness of same, agg. after walking, generally appearing while sitting, while cramps in hands always appear after using them.

Loss of sensation in tips of fingers.

Numbness of tips of fingers.

Crawling in tips of fingers as if something alive were creeping under skin or as if fingers were asleep, as from pressure upon arm.

Peculiar prickling feeling in tips of fingers; they are sensitive to cold.

Painful swelling of fingers.

Violent pains in finger tips.

Gangrene of fingers; senile gangrene.

Shifting pains first through my hands from one finger to another, then through the wrist joint.

Wrist weakened so it was painful to lift weight.

Sensation of burning on left hand as though irritated with Cayenne; warm after rubbing.

Dull, spasmodic pain from shoulder to elbow along median nerve, worse on right side and in morning.

Lower limbs

Hammering, tearing pain in both thighs increased by motion.

Legs heavy and tired.

Tingling in legs.

Creeping feeling in anterior femoral and posterior tibial regions.

Shuffling gait as if feet were dragged along.

Rheumatic pains of joints.

Cramps in calves of legs and soles of feet, disturbing sleep at night and hindering walking in pregnant women.

After am attack of cholera cramps in calves and sensation of numbness and formication in toes.

Cramp in calves.

Burning in feet.

The feet seem asleep and stiff.

Toes of right foot spasmodically drawn upwards, continuously during day and occasionally at night, causing a peculiar limping gait; this cramp was accompanied by no pain, but by a very tiresome sensation rendering walking, particularly going up and down stairs,

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