This study proposes a mixed integer linear programming (MILP) model to optimize the spillways scheduling for reservoir flood control. Unlike the conventional reservoir operation model, the proposed MILP model specifies the spillways status (including the number of spillways to be open and the degree of the spillway opened) instead of reservoir release, since the release is actually controlled by using the spillway. The piecewise linear approximation is used to formulate the relationship between the reservoir storage and water release for a spillway, which should be open/closed with a status depicted by a binary variable. The control order and symmetry rules of spillways are described and incorporated into the constraints for meeting the practical demand. Thus, a MILP model is set up to minimize the maximum reservoir storage. The General Algebraic Modeling System (GAMS) and IBM ILOG CPLEX Optimization Studio (CPLEX) software are used to find the optimal solution for the proposed MILP model. The China’s Three Gorges Reservoir, whose spillways are of five types with the total number of 80, is selected as the case study. It is shown that the proposed model decreases the flood risk compared with the conventional operation and makes the operation more practical by specifying the spillways status directly.