Get to know your liver and how to can
protect it!
Liver is involved in about 500
different daily functions critical to our health. Liver works 24/7 to eliminate
biological and environmental toxins. Liver participates in regulating blood
glucose and cholesterol. Different hormones, enzymes, and blood clotting
factors are produced in the liver. Plus, Secreted bile from the liver helps with
digestion.
Proper liver function is
necessary to all aspect of health, yet its health is compromised by constant
exposure to toxins, drugs, unhealthy diets, obesity, high blood sugar,
infections, and many other factors.
One of the common causes of the
chronic liver disease is known as Non Alcoholic Fatty Liver Disease, which is
defined as accumulation of fat in the liver cells, and it is directly linked to
high fat and carbohydrate consumption and a lifestyle with very little physical
activity. Non Alcoholic Fatty Liver is
part of the metabolic syndrome including cardiovascular diseases and diabetes
with spectrum of symptoms. If Non Alcoholic Fatty Liver not being taken care
of, it will progress to Non Alcoholic Steatohepatitis which a dangerous
condition leading to liver fibrosis, cirrhosis, and even liver cancer.
While there is no
adequate pharmaceutical treatment for Non Alcoholic Fatty Liver, multiple
number of studies confirm that
Milk thistle seed extract is able to improve and protect
gallbladder and liver function. It prevents liver damage and reduces the
elevated Liver enzymes. The benefits of the milk thistle is linked to a
compound with very potent antioxidant and anti inflammatory properties called
Silymarin. Silymarin itself
contains a molecule called
Silybin
which is the most active part of the Silymarin. As a result, the higher concentrations of
Silymarin provides better therapeutic effects.
Silybin however is not well
absorbed through the digestive system. Human studies has shown to when it is
combined with
Phosphatidylcholine, Silybin's absorption and concentration
in the liver is significantly increased. This
phytosome combination is shown to restore liver function and normalize
liver enzymes in cases of Non Alcoholic Fatty Liver. It improves insulin
resistance in diabetics , and it is able to reduce liver damage in patients with
viral hepatitis, as well as to increase the life span of those with critical
liver damage and cirrhosis.
Daily supplementation with
vitamin E has been proven to benefit the liver health in
different ways. Primarily vitamin E as a powerful antioxidant protects the
liver cells by providing preventative benefits against developing liver diseases
including fatty liver. Studies have found patients of Non Alcoholic Fatty
Liver have low blood levels of Vitamin E
and that even more increases the risk of oxidative stress on the liver cells resulting
in high inflammation, cellular death, and further tissue damage . When these
patients took vitamin E, their liver inflammatory markers and liver enzymes
were reduced substantially. Also monitoring Diabetic patients who supplemented
with vitamin E showed improvement in their insulin sensitivity, lower fasting
blood sugar level and ultimately a better liver function.
Long term human based researches
indicates the importance of Omega 3 fatty acids to prevent and improve many
health conditions, and that is in fact is very applicable to Non Alcoholic
Fatty Acid condition. Therapeutic dosage of
Omega 3 Fatty Acids
daily not only lowers blood Triglyceride, Fasting Blood Sugar and inflammatory
markers, but also improves the liver tissue and its blood circulation when
observed by ultrasound within 6 months from supplementation.
Constant exposure to
verity of toxins makes liver cells to become less able to produce enough
Glutathione.
Glutathione (GSH) is a sulfur rich antioxidant
produced naturally by liver cells and participates in detoxification pathways.
However, when liver cells are damaged or going through oxidative stress, they
will not produce adequate amount of Glutathione. So higher amount of toxins
and lack of Glutathione production hand in hand amplifies the cellular damage.
Simply increasing intake of
Sulfur rich foods like
Garlic and Cruciferous
vegetables, and
Highly pure whey protein can increase the
levels of Glutathione. Also supplementation with
Selenium, NAC, Alpha Lipoic Acid, SAMe, Methylcobalamin, B6 (P-5-P), Folate, Vitamin E and C will help to recycle the produced Glutathione
in the body. Some people due to gene
impairments are unable to produce Glutathione properly; so oral supplementation
or intravenous injection is recommended.
Articles
and products featured by Health Palace are collected from a variety of sources
and are provided as a service by Health Palace. These newsletters, while of
potential interest to readers, do not necessarily represent the opinions nor
constitute the advice of Health Palace. Presented materials are only for information
purposes and do not intent to treat, cure, or prevent any disease.
References:
1.Masuoka HC, Chalasani N. Nonalcoholic
fatty liver disease: an emerging threat to obese and diabetic individuals.
Ann N Y Acad Sci. 2013 Jan 30.
3.Abenavoli L, Capasso R, Milic N,
Capasso F. Milk thistle in liver diseases: past, present, future.
Phytother Res. 2010
Oct;24(10):1423-32.
4.Schrieber SJ, Wen Z, Vourvahis M, et
al. The pharmacokinetics of silymarin is altered in patients with hepatitis C
virus and nonalcoholic Fatty liver disease and correlates with plasma
caspase-3/7 activity. Drug Metab Dispos. 2008 Sep;36(9):1909-16.
5.Serviddio G, Bellanti F, Giudetti AM,
et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a
rodent model of nonalcoholic steatohepatitis. J Pharmacol Exp Ther. 2010
Mar;332(3):922-32.
6.Aleynik
SI, Leo MA, Ma X, Aleynik MK, Lieber CS.
Polyenylphosphatidylcholine
prevents carbon tetrachloride-induced lipid peroxidation while it attenuates
liver fibrosis. J Hepatol. 1997 Sep;27(3):554-61.
7.Salamone F, Galvano F, Cappello F,
Mangiameli A, Barbagallo I, Li Volti G. Silibinin modulates lipid homeostasis
and inhibits nuclear factor kappa B activation in experimental nonalcoholic
steatohepatitis.
Transl Res. 2012
Jun;159(6):477-86.
8.Salamone
F, Galvano F, Marino Gammazza A, et al.
Silibinin improves
hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
Dig Liver Dis. 2012
Apr;44(4):334-42.
9.Kim M, Yang SG, Kim JM, Lee JW, Kim
YS, Lee JI. Silymarin suppresses hepatic stellate cell activation in a dietary
rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic
stellate cells.
Int J Mol Med. 2012
Sep;30(3):473-9.
10.Magliulo E, Gagliardi B, Fiori GP. Results of a double blind study on the effect of silymarin in the
treatment of acute viral hepatitis, carried out at two medical centres
(author’s transl).
Med Klin. 1978
Jul 14;73(28-29):1060-5.
11.Schuppan D, Gorrell MD, Klein T, Mark M, Afdhal NH. The challenge of
developing novel pharmacological therapies for nonalcoholic steatohepatitis.
Liver Int. 2010 Jul;30(6):795-808.
12.Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic
studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human
subjects.
Eur J Drug Metab Pharmacokinet. 1990;15(4):333-38.
13.Benda L, Dittrich H, Ferenzi P, Frank H, Wewalka F. The influence of
therapy with silymarin on the survival rate of patients with liver cirrhosis
(author’s transl).
Wien Klin Wochenschr. 1980
Oct 10;92(19):678-83.
14.Lirussi F, Azzalini L, Orando S, Orlando R, Angelico F. Antioxidant
supplements for nonalcoholic fatty liver disease and/or steatohepatitis.
Cochrane Database Syst Rev. 2007 Jan 24(1):CD004996.
15.Bernal-Reyes R, Escudero RB. Treatment of nonalcoholic steatohepatitis (NASH). A comparative study of
ursodeoxycholic acid and alpha-tocopherol. A preliminary report. Rev
Gastroenterol Mex. 2002 Apr-Jun;67(2):70-5.
17.Bell H, Bjorneboe A, Eidsvoll B, et al. Reduced concentration of hepatic
alpha-tocopherol in patients with alcoholic liver cirrhosis. Alcohol Alcohol.
1992 Jan;27(1):39-46.
18.Bahcecioglu IH, Yalniz M, Ilhan N, Ataseven H, Ozercan IH. Levels of
serum vitamin A, alpha-tocopherol and malondialdehyde in patients with
nonalcoholic steatohepatitis: relationship with histopathologic severity. Int J
Clin Pract. 2005 Mar;59(3):318-23.
19.Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming
growth factor-beta1 level and efficacy of alpha-tocopherol in patients with
nonalcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther. 2001
Oct;15(10):1667-72.
20.Federico A, Trappoliere M, Tuccillo
C, et al.
A new silybin-vitamin E-phospholipid
complex improves insulin resistance and liver damage in patients with
nonalcoholic fatty liver disease: preliminary observations. Gut. 2006
Jun;55(6):901-2.
22.Ukropec J, Reseland JE, Gasperikova D, et al. The hypotriglyceridemic
effect of dietary n-3 FA is associated with increased beta-oxidation and
reduced leptin expression. Lipids. 2003 Oct;38(10):1023-9.
23.Xin YN, Xuan SY, Zhang JH, Zheng MH, Guan HS. Omega-3 polyunsaturated
fatty acids: a specific liver drug for nonalcoholic fatty liver disease
(NAFLD). Med Hypotheses. 2008 Nov;71(5):820-1.
2.Kaser S, Ebenbichler CF, Tilg H.
Pharmacological and non-pharmacological treatment of nonalcoholic fatty liver
disease. Int J Clin Pract. 2010 Jun;64(7):968-83.
16.Medina J, Moreno-Otero R.
Pathophysiological basis for antioxidant therapy in chronic liver disease.
Drugs. 2005;65(17):2445-61.
21.Martin de Santa Olalla L, Sanchez Muniz FJ, Vaquero MP. N-3 fatty acids in glucose metabolism and insulin sensitivity.
Nutr Hosp. 2009 Mar-Apr;24(2):113-27.
24.Kwon do Y, Jung YS, Kim SJ, Park
HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress
in nonalcoholic fatty liver are alleviated by betaine sup
25.Oz HS, Im HJ, Chen TS, de
Villiers WJ, McClain CJ. Glutathione-enhancing agents protect against
steatohepatitis in a dietary model. J Biochem Mol Toxicol.
2006;20(1):39-47.plementation in rats. J Nutr. 2009 Jan;139(1):63-8.
26.Millea PJ. N-acetylcysteine:
multiple clinical applications. Am Fam Physician. 2009 Aug 1;
27.Mehta K, Van Thiel DH, Shah N,
Mobarhan S. Nonalcoholic fatty liver disease: pathogenesis and the role of
antioxidants. Nutr Rev. 2002 Sep;60(9):289-93.80(3):265-9.
Alpha Science Liver Cleanse
Pure Encapsulations Liposomal Glutathione 60 Softgels
Aor Antioxidan Synergy 120 Veg Capsules
This formula detoxifies and drains toxins from the liver while supporting and regenerating weak tissue. The antioxidant properties of these herbs are made more significant due to the greater than normal level of free radicals generated during the cleansing process...
Read more
Offers the key antioxidant glutathione in an enhanced absorption liposomal form
Purified phosphatidylcholine delivery system offers natural liposomal formation due to the hydrophobic and hydrophilic nature of phospholipids...
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Includes the complete "Antioxidant Network," the body's five-member antioxidant defense and recycling system. Most antioxidants lose their protective power once they have quenched a single free radical... Read more
Aor Liver Support 180 Veg Capsules
Thorne MediClear 34.57 Oz
St Francis HepatoDR 250 Ml
Contains ingredients that help to support liver function and contains antioxidants for the maintenance of good health.
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Rice protein, pea protein, and accessory nutrients to support liver detoxification.MediClear is a rice and pea protein-based dietary supplement... Read more
Traditionally used in Herbal Medicine to support liver function and as an alterative to help remove accumulated waste products via the kidneys, skin, and mucous membranes...Read more