The tip behind a highway map
In a elementary and naked staffroom with a window unaware a
line of immature African mahogany trees, Dr Le Sy Vinh during a Faculty of
Information Technology during a University of Engineering and Technology –
Vietnam National University in Hanoi (VNU-UET) talks about a dream of
his, and his colleagues, of sequencing a Vietnamese tellurian genome.
Combining both information record and biotechnology, a plan has
the appearance of 12 members from VNU-UET, a VNU Information
Technology Institute, a Hanoi University of Science and Technology
(HUST) and Oxford University.
The genome of a tellurian being contains all of a genetic information
that determines their biological growth and characteristics. Once
the genome of an particular is sequenced and analysed, scientists can
reveal information about a growth routine of that particular and
forecast diseases from that they are during risk of suffering. The genomes
of dual apart people are probably a same with customarily 0.1%
difference.
Using specialised apparatus and with consummate analysis, scientists
can pull a map of a tellurian genome like sketch a map of highways. By
following and adding critical information to any “route”, scientists
can establish that genes are obliged for protein metabolism, which
genes means certain diseases and genetic differences that make one
person opposite from another.
Individuals of a same ethnicity customarily bear a common biological
characteristics of that group. If a genomes of many people are
sequenced, we can have a clearer pattern of a biological development
and characteristics of an ethnicity as good as their story of
development and migration. Beyond that, it helps finish a migration
routes of tellurian races on a tellurian anthropomorphic map. Dr Vinh says on
that map, Vietnam stays a puzzling black spot. During their
research, his organisation also paid tighten courtesy to how emigration relates
to a Vietnamese people. According to Dr Vinh, they have achieved some
early formula and will continue a attempt to decode many more
information.
Wide-ranging applications
Adding Vietnam to a list of 20 countries successfully sequencing
the tellurian genome of their peoples is a systematic breakthrough. In the
near future, there will be an focus that can detect some-more than
3,000 genetic disorders in sequence to rise early impediment and
treatment plans. The outcome of a plan will widespread over the
laboratory.
In an talk with Nhan Dan, Dr Le Sy Vinh common his
vision about unsentimental applications for this plan in a future. He
says costs aside, a initial emanate confronting them is building a full
process in sequence to build and analyse a genome of an individual, from
collecting and analysing data, to anticipating out and bargain new
knowledge.
This is a vast and formidable mathematical problem with many
different stages, requiring a extended believe in mixed disciplines
from molecular biology to information technology, generally vast data
processing. Thus building a finish routine that is suitable to
Vietnam’s conditions is a many formidable problem.
Regarding computing capabilities, HUST and VNU-UET have large
computing systems though they are not dedicated to estimate vast maths
problems such as building and analysing a tellurian genome, says Dr Vinh,
adding that they have to pattern an suitable computing routine that
can run on existent systems.
The whole routine from a commencement to a proclamation of the
successful sequencing in 2013 lasted about 3 years. At a finish of
2013, a organisation perceived tender information on a genome of a Vietnamese
individual.
The information contained some-more than 108 billion nucleotides
containing a genetic information of that individual. On that basis,
the investigate organisation began building and analysing a genome of this
individual regulating complicated and rarely accurate record and computing
methods on VNU-UET and HUST’s computing systems.
The investigate organisation used bioinformatics methods and collection to build the
genome from tender information collected, and analyse a genome to work out and
understand a differences compared with a customary tellurian genome data
as good as a genomes of other races.
The outcome is that a genome
sequenced by a organisation contained some-more than 3 million
single-nucleotide polymorphisms (SNPs) compared with a tellurian reference
genome. Many new SNPs are customarily found in a Vietnamese tellurian genome.
Analytical information also found some other new constructional polymorphisms.
The routine to build and analyse a tellurian genome brings many benefits
to other fields, particularly medicine, pharmaceuticals, biotechnology and
anthropology. More importantly, genetic investigate and investigate will help
doctors digest individually-oriented impediment and treatment
strategies.
There are many diseases caused by gene mutations and these studies
will act as a predecessor to find damaging changes, thereby discovering
diseases that a chairman could humour from, and operative out surety and
therapeutic measures tailored to that individual. Dr Vinh says in the
future a organisation will work with medical scientists and vast hospitals to
provide this service.
Article source: http://english.vietnamnet.vn/fms/science-it/124074/journey-to-sequence-the-vietnamese-human-genome.html