On Dec. 3, 2014, Carolina announced a $100 million commitment from Fred Eshelman to the Eshelman School of Pharmacy.
The commitment is the largest from an individual in UNC history and the largest ever to a U.S. pharmacy school. It created the Eshelman Institute for Innovation to pursue high-risk, high-reward ideas that advance innovation in pharmacy education, research and health care.
Two times per year, the institute will seek proposal submissions from the Eshelman School of Pharmacy’s faculty, staff and students for big ideas and innovations that have measurable impact and lead to transformative change in:
Basic and applied research in the pharmaceutical sciences
Health-care quality, practice and policy
Health-sciences education and educational research
Business processes and practices
For the inaugural cycle, 24 of 53 submitted proposals were funded, with a total of nearly $9.4 million awarded. They were:
Tier 1: Up to a total of $50,000
Delesha Carpenter, Division of Pharmaceutical Outcomes and Policy
Non-invasive Technology to Continuously Monitor and Improve Patient Medication Adherence
Alexander Golbraikh, Division of Chemical Biology and Medicinal Chemistry
Large-Scale Polypharmacology Modeling Using Deep Learning
Shawn Hingtgen, Division of Molecular Pharmaceutics
Cytotoxic Stem Cell Therapy for Pediatric Brain Cancer
Weigang Huang, Division of Chemical Biology and Medicinal Chemistry
Profiling Cellular Phosphoinositide Metabolism for Disease Diagnosis
Robert Hughes, Division of Chemical Biology and Medicinal Chemistry
Optogenetics, Cytoskeletal Dysregulation, and Disease
Alexander Kabanov, Division of Molecular Pharmaceutics
Carolina Nanoformulation Workshop
Alexander Kabanov, Division of Molecular Pharmaceutics/Center for Nanotechnology in Drug Delivery
RECOPE: Reverse Conceptual Product Engineering
Dmitri Kireev, Center for Integrative Chemical Biology and Drug Discovery
Molecular Simulations of Ultra-Large Biological Systems
Samuel Lai, Division of Molecular Pharmaceutics
Shoebox-Sized Plasmapheresis Machine for Cheap & Rapid Generation of Convalescent Serum in Africa
Rihe Liu, Division of Chemical Biology and Medicinal Chemistry
Decipher a Highly Specific Biomarker for Targeted Treatment of Pancreatic Cancer
Craig Lee, Division of Pharmacotherapy and Experimental Therapeutics
Solving the Mystery of Highly Variable Drug Disposition in Pregnant Women: Are Unique Hepatic Drug Metabolizing Enzymes Activated During Pregnancy?
Xin Ming, Division of Molecular Pharmaceutics
P-Glycoprotein Targeted Antibody Conjugates for Combating Chemoresistant Tumors
Bill Zamboni, Division of Pharmacotherapy and Experimental Therapeutics
Enhancing Tumor Delivery of Nanoparticle Anticancer Agents Using Microbeam Radiation Therapy
Tier 2: Up to a total of $200,000
Emily Hull-Ryde, Division of Chemical Biology and Medicinal Chemistry/Center for Integrative Chemical Biology and Drug Discovery
Controlling the Mucus That Kills Pulmonary Patients
Samuel Lai, Division of Molecular Pharmaceutics
Carolina E(I) Lab: A Multidisciplinary, Entrepreneurial Experience in Transforming Bold Ideas Into Successful Ventures
Jacqui McLaughlin, Division of Practice Advancement and Clinical Education
Transforming Data into Knowledge: Fostering Institutional Effectiveness through Real-Time Analytics
Tier 3: Up to a total of $750,000
Shawn Hingtgen, Division of Molecular Pharmaceutics
Transdifferentiation: A Novel Approach to Personalized Cancer Therapy
Leaf Huang, Division of Molecular Pharmaceutics
Priming the Liver to Resist Cancer Metastasis
Samuel Lai, Division of Molecular Pharmaceutics
Engineered Antibodies With Carefully Tuned Mucin-Affinity for Enhanced Mucosal Protection
David Lawrence, Division of Chemical Biology and Medicinal Chemistry
Light-Triggered Launching of Anti-Glioblastoma Therapeutics From Cellular Silos
Jian Liu, Division of Chemical Biology and Medicinal Chemistry
Developing Carbohydrate-Based Medicines
Mary McClurg, Division of Practice Advancement and Clinical Education
Innovations in Practice Transformation: Advancing Medication Optimization in Primary Care
Tier 4: Up to a total of $2 million
Alexander Tropsha, Division of Chemical Biology and Medicinal Chemistry
Center for Innovation in Pharmacy Simulation (CIPS)
Tim Willson, Structural Genomics Consortium – UNC
The SCG-UNC: A Center for Open and Collaborative Target Discovery
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