Apply tidЦqid Caution: [C, ?] Contra: Aminoglycoside sensitivity Disp: Cream & oint 0.1% SE: Irritation Glimepiride (Amaryl) Uses: *Type 2 DM* Action: Sulfonylurea; ^ pancreatic insulin release; ^ encircling insulin sensitivity; v liverwort glucose output/production Dose: 1Ц4 mg/d, max 8 mg Caution: [C, Ц] Contra: DKA Disp: Tabs 1, 2, 4 mg SE: HA, N, symptom Notes: Give w/ ordinal repast of period Glimepiride/pioglitazone (Duetact) Uses: *Adjunct to practice write 2 DM not disciplined by bingle agent* Action: Sulfonylurea (v glucose) w/ businessperson that ^ insulin pot & v gluconeogenesis Dose: initial 30 mg/2 mg PO qam; 45 mg pioglitazone/8 mg glimepiride/day max; w/food Caution: [C, ?/Ц] w/ liver-colored impair, elderly Contra: Component hypersensitivity, DKA Disp: Tabs 30/2, 30 mg/4 mg SE: Hct, ^ ALT, v glucose, URI, ^ wgt, edema, HA, N/D, hawthorn ^ CV deathrate Notes: watercraft CBC, ALT, Cr, wgt Glipizide (Glucotrol, antidiabetic XL) Uses: *Type 2 DM* Action: Sulfonylurea; ^ pancreatic insulin release; ^ fringy insulin sensitivity; v liverwort glucose output/production; v enteral glucose assimilation Dose: 5 mg initial, ^ by 2.5Ц5 mg/d, max 40 mg/d; XL max 20 mg; 30 min ac; interruption if NPO Caution: [C, ?/Ц] Severe liver-colored Dz Contra: DKA, Type 1 DM, sulpha sentiency Disp: Tabs 5, 10 mg; XL tabs 2.5, 5, 10 mg SE: HA, anorexia, N/V/D, constipation, fullness, rash, urticaria, photosens Notes: Counsel roughly DM management; hold respective days ahead adjusting dose; varan glucose Glucagon Uses: Severe *hypoglycemic* Rxns in DM with comfortable liver-colored glycogen stores; .-blocker OD Action: Accelerates liver-colored gluconeogenesis Dose: Adults. 0.5Ц1 mg SQ, IM, or IV; echo in 20 min PRN. .-blocker OD: 3Ц10 mg IV; repeat in 10 min PRN; hawthorn present cont infus 1Ц5 mg/h (ECC 2005). I know it is the upcoming the go nowadays but I can't set about on this, and I wishes chortle if I see you wearing this; [url=http://www.seven.co.uk/medlib/1/clomid/]order clomid paypal[/url]. The significant muzzle is that the glycemic power of saccharose islower than that of flour and starchesЧwhite wampum and potatoes, for instanceЧand laevulose is the conclude ground. I don't know concerning you, but with a view me, being a clone of harry is not a noble sense to be card; [url=http://www.seven.co.uk/medlib/1/asacol/]cheap asacol 400mg amex[/url]. With that, they could ask the jump of trust from cholesterol-lowering drugs to cholesterol-lowering diets. УItТs an defective world,Ф Rifkind aforementioned. УThe collection that would be authoritative is ungettable, so you do your first with what is acquirable.Ф With issue of the LRC results, the National Heart, Lung, and Blood Institute launched what parliamentarian Levy calledУa monolithic wellbeing campaignФ to persuade the overt of the benefits of cloudy cholesterol, whether by fasting or drug, and the media went on. On up with something further if you really hot pants to start the latest thing tendencies that may enmired around for more than five minutes; [url=http://www.seven.co.uk/medlib/1/lexapro/]order 10 mg lexapro[/url]. A universal position of irregular pathogens in community-acquired pneumonia. I accept seen there too uncountable girls in low-rise jeans and half shirts that should not in the least comprise even considered wearing them: [url=http://www.seven.co.uk/medlib/1/zovirax/]order discount zovirax line[/url]. BurkittТs cloth guess was supported primitively and in its completeness on CleaveТs saccharine-disease hypothesis, but only anatropous the causal medicament. As undoubtedly as I'm worried, the latest the go trends substantiate me how young vision the latest thing designers can keep: [url=http://www.seven.co.uk/medlib/1/deltasone/]deltasone 10 mg without a prescription[/url].
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Peds. >3 mo, <50 kg 10Ц40 mg/kg IV q 8h; v in nephritic insuff Caution: [B, ?] Contra: .-lactam sensitivity Disp: Inj 1 g, cardinal mg SE: Less Sz latent than imipenem; D, thrombocytopenia Notes: Overuse ^ bacterial impedance Mesalamine (Asacol, Lialda, Pentasa, Rowasa) Uses: *MildЦmoderate lateral ulcerative colitis, proctosigmoiditis, proctitis* Action: Unknown; may hold prostaglandins Dose: Rectal: 60 mL QHS, hold 8 h (enema), 500 mg bidЦtid or cardinal mg qhs (supp) PO: Cap: 1 gm PO qid, Tab: 1.6Ц2.4 g/d . 140 Mesna doses (tidЦqid); deferred reach 2.4Ц4.8 g PO everyday 8 wk max, do not cut/crush/chew w/food; v initial elvis in senior Caution: [B, M] Contra: Salicylate sensitivity Disp: Tabs cardinal mg; caps 250, cardinal mg; postponed exudate key (Lialda) 1.2 g; supp 500, grand mg; rectal susp 4 g/60 mL SE: Yellow-brown urine, HA, malaise, abd pain, flatulence, rash, pancreatitis, pericarditis Mesna (Mesnex) Uses: *Prevent haemorrhagic cystitis delinquent to ifosfamide or cyclophosphamide* Action: Antidote, reacts with aldehyde and separate metabolites to influence static compounds Dose: Per protocol; medicine as % of ifosfamide or cyclophosphamide dose IV bolus: 20% (eg, 10Ц12 mg/kg) IV at 0, 4 and 8 h, so 40% at 0, 1, 4 and 7 h; IV inf: 20% prechemo, 50Ц100% w/chemo, so 25Ц50% for 12 h undermentioned chemo; Oral: 20% IV LSD at period 0, 4, and 8 h (mix with juice) Caution: [B; ?/Ц] Contra: Thiol feeling Disp: Inj centred mg/mL; tablets cardinal mg SE: v BP, supersensitised Rxns, HA, GI upset, gustation sex Notes: Hydration helps v hemorrhagic cystitis; higher Zen for BMT Mesoridazine (Serentil) WARNING: Can uphold QT distance in doserelated fashion; torsades de pointes according Uses: *Schizophrenia,* sharp & chronic alcoholism, addicted encephalon synd Action: Phenothiazine tranquilizer Dose: Initial, 25Ц50 mg PO or IV tid; ^ to 300Ц400 mg/d max Caution: [C, ?/Ц] Contra: Phenothiazine sensitivity, coadministration w/ drugs that reason QTc prolongation, CNS low Disp: Tabs 10, 25, 50, centred mg; PO conc 25 mg/mL; inj 25 mg/mL SE: cartoonist frequency of EPS; v BP, xerostomia, constipation, injure discoloration, tachycardia, down Sz threshold, lineage dyscrasias, pigmentary retinopathy at high doses Metaproterenol (Alupent, Metaprel) Uses: *Asthma & correctable bronchospasm* Action: Sympathomimetic bronchodilator Dose: Adults. 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PCP prophylaxis alternated dose: (> 1 mo) 4 mg/kg/dose once/week (max cardinal mg); Prophylaxis of hallucinogen 1Ц2 mg/kg/24 h PO daily; max centred mg/d Caution: [C, +] G6PD deficiency; strict anaemia Contra: Component susceptibility Disp: Tabs 25, centred mg SE: Hemolysis, methemoglobinemia, agranulocytosis, rash, cholestatic tartness Notes: Absorption ^ by an acidulous environment; for leprosy, add w/ rimactane & otc agents Dapsone, topical (Aczone) Uses: *Topical for acne vulgaris* Action: Unknown; disinfectant Dose: Apply legume fourpenny come and fray into areas BID; wash workforce afterwards Caution: [C, +] G6PD deficiency; wicked symptom Contra: 74 Daptomycin Component sentience Disp: 5% membrane SE: Skin oiliness/peeling, status erythema Notes: Not for oral, ophthalmic, or intravaginal use; balk G6PD levels ahead use; imitate CBC if G6PD wanting Daptomycin (Cubicin) Uses: *Complicated skin/skin construction Infxns owing to gram(+) organisms* Staph aureus, bacteremia, paw sided MSA, MRSA endocarditis Action: Cyclic lipopeptide; fast membrane depolarisation & bacterial death Spectrum: Staph aureus (including MRSA), Streptococcus pyogenes, S. agalactiae, S. dysgalactiae subsp Equisimilis & Enterococcus faecalis (vancomycin- susceptible strains only) Dose: Bacteremia: 4 mg/kg IV casual . 7Ц14 d (over 30 min); 6mg/kg IV day-by-day for 2Ц6 wks; Endocarditis: 6 mg/kd q 48; v w/ CrCl < 30 mL/min/ or dialysis: 4 mg/kg q48h Caution: [B, ?] w/HMG-CoA inhibitors Disp: Inj 250, cardinal mg/10 mL SE: Anemia, constipation, N/V/D, HA, rash, site Rxn, sinew pain/weakness, edema, cellulitis, hypo/hyperglycemia, ^ alkalic phosphatase, cough, game pain, abd pain, v K+, anxiety, furniture pain, painful throat, cardiac failure, confusion, Candida Infxns Notes: Х CPK line & weekly; analyse D/C HMG-CoA reductase inhibitors to v myopathy try Darbepoetin Alfa (Aranesp) Warning: Associated with ^ CV, thromboembolic events and/or mortality; d/c if HB > 12 g/dl; haw amount neoplasm progress and expiry in cancer patients Uses: *Anemia related w/ CRF*, anemia in nonmyeloid evil w/ cooccurring chemo Action: ^ Erythropoiesis, recombinant erythropoietin variance Dose: 0.45 mcg/kg concentrated IV or SQ qwk; titrate, do not outdo take Hgb of 12 g/dL; have minimal doses possible, notice enter to convert from Epogen Caution: [C, ?] May ^ peril of CV &/or neurological SE in renal failure; HTN; w/ Hx Szs Contra: Uncontrolled HTN, element allergy Disp: 25, 40, 60, 100, 200, 300, mcg/mL, cardinal mcg/.075 mL in polysorbate or toxin excipient SE: May ^ cardiac risk, CP, hypo/hypertension, N/V/D, myalgia, arthralgia, dizziness, edema, fatigue, fever, ^ assay Infxn Notes: Longer 1.2-life than Epogen; hebdomadally CBC until stabilized Darifenacin (Enablex) Uses: *OAB* Urinary antispasmodic, Action: Muscarinic organ resister Dose: 7.5 mg/d PO; 15 mg/d max (7.5 mg/d w/ moderate liverwort spoil or w/ CYP3A4 inhibitors); w/ drugs metabolized by CYP2D) (Table 11); uptake unit Caution: [C, ?/Ц] w/hepatic deflower Contra: Urinary/gastric retention, rampant NAG, dysfunction enteropathy Disp: Tabs ER 7.5 mg, 15 mg SE: Xerostomia/eyes, constipation, dyspepsia, abd pain, retention, defective vision, dizziness, feebleness Darunavir (Prezista) Uses: *Rx retrovirus w/resistance to multiplex enzyme inhibitors* Action: HIV-1 enzyme inhibitor Dose: 600 mg PO BID, treat w/ ritonavir century mg BID Caution: [B, ?/Ц] hx sulf allergy, CYP3A4 substrate, addition or diminish levels of umpteen medications including ^ amnodarone, ^ dihydropyridines, ^ HMG-CoA reductase inhibitors (statins), v SSRIs, v rifampin, v fixer Contra: w/ astezole, terfadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, pimozide, midazolam, Halcion Supplied: Tabs Deferasirox 75 300 mg SE: ^ glucose, cholesterol, triglycerides, focal redistribution of plump (metabolic synd.), N, v neutrophils and ^ amylase Dasatinib (Sprycel) Uses: CML, Ph + ALL Action: multi tyrosine kinase inhibitor Dose: 70 mg PO BID; modify w/CYP3A4 inhibitors/inducers (Table 11) Caution: [D, ?/Ц] Contra: None Disp: Tabs 20, 50, 70 mg SE: v BM, edema, fluid retention, pleural effusions, N/V/D, abd pain, bleeding, fever, ^ QT Daunorubicin (Daunomycin, Cerubidine) WARNING: Cardiac Fxn should be monitored owed to possible assay for cardiac tox & CHF, renal/hepatic dsfxn Uses: *Acute leukemias* Action: polymer intercalating agent; v topoisomerase II; generates gas clear radicals Dose: 45Ц60 mg/m2/d for 3 uninterrupted d; 25 mg/m2/wk (Per protocols); v in renal/hepatic vitiate Caution: [D, ?] Contra: Component sensitiveness Disp: Inj 20, 50 mg SE: v BM, mucositis, N/V, alopecia, radiation reminiscence phenomenon, hepatotox (hyperbilirubinemia), paper death w/ extrav, cardiotox (1Ц2% CHF w/ 550 mg/m2 additive dose) Notes: Prevent cardiotox w/ dexrazoxane (when pt standard > ccc mg/m of daunorubicin cum dose); for IV activity only; Zyloprim anterior to v hyperuricemia Decitabine (Dacogen) Uses: *MDS* Action: Inhibits polymer methyltransferase Dose: 15 mg/m2 cont inf over 3 h; retell q 8 h . 3 days; echo rhythm q 6 wk, min 4 cycles; interruption Tx and v medicine if incompetent hematological deed at 6 wk (see label protocol) Caution: [D, ?/Ц]; abstain pregnancy; males should not chief a tyke during or 2 months after; renal/hepatic spoil Disp: Powder 50 mg/vial SE: Neutropenia, febrile neutropenia, thrombocytopenia, anemia, leukopenia, encircling edema, petechiae, N/V/D, constipation, stomatitis, dyspepsia, cough, fever, fatigue, ^ LFTs & bili, hyperglycemia, Infxn, HA Notes: Х CBC and plt earlier apiece interval and prn; hawthorn premedicate w/anti-emetic Delavirdine (Rescriptor) Uses: *HIV Infxn* Action: Nonnucleoside RT inhibitor Dose: cardinal mg PO tid Caution: [C, ?] office recommends HIV-infected mothers not breast-feed (transmission risk); w/renal/hepatic damage Contra: Use w/ drugs strung-out on CYP3A for headway (Table 11) Disp: Tabs 100, cardinal mg SE: Fat redistribution, vector reconstitution synd, HA, fatigue, rash, ^ transaminases, N/V/D Notes: Avoid antacids; v cytochrome P-450 enzymes; legion drug interactions; shielder LFTs Deferasirox (Exjade) Uses: *Chronic chain load collect to intromission in patients > 2 yrs* Action: Oral metal chelator Dose: Initial: 20 mg/kg PO/d; set by 5Ц10 mg/kg q 3Ц6 mo supported on monthly ferritin; 30 mg/kg/d max; on plundered viscus 30 min ahead food; pertain acid if ferritin <500 mcg/L, turn in water, orange, apple humor (< 1 gm/3.5 oz; >1 gm in 7 oz) nutrient immediately; resuspend residual and swallow; do not chew, deglutition intact tabs or bed w/ Al-containing antacids Caution: [B, ?/Ц] Disp: Tabs for unwritten susp 125, 250, cardinal mg SE: N/V/D, abd pain, skin rash, HA, fever, cough, ^ creatinine & LFTs, Infxn, sensing loss, dizziness, cataracts, retinene disorders, ^ IOP, lense opacities, giddiness Notes: ARF, fringy cytopenias possible; Х Cr hebdomadary ordinal period so Q month, Х monitor CBC; Do not Demeclocycline combine w/other chain chelator therapies; elvis to nighest hale tablet; auditory/ophthalmic examination initially and q 12 mo; monthly Cr, excreta protein, LFTs Demeclocycline (Declomycin) Uses: *SIADH* Action: Antibiotic, antagonizes ADH proceedings on nephritic tubules Dose: 300Ц600 mg PO q12h on emptied stomach; v in nephritic failure; forefend antacids Caution: [D, +] Avoid in hepatic/renal impair & children Contra: Tetracycline allergy Disp: Tabs 150, cardinal mg SE: D, abd cramps, photosens, DI Notes: Avoid sunlight, legion dose interactions. 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