Sugar may have ~ing as damaging to the brain as extreme abuse
Posted by Big Rat put ~ Campus on Feb 16, 2016 in Rat News | Subscribe
We wholly know that cola and lemonade aren’t vast for our waistline or our dental health, but our new study on rats has diffuse light on just how much injure sugary drinks can also do to our brain.
The changes we observed to the sphere of the brain that controls emotional behaviour and cognitive performance were more extensive than those caused by extreme early life stress.
It is known that harmful experiences early in life, such like extreme stress or abuse, increase the risk of poor mental health and psychiatric disorders later in life.
The consist of of traumatic events (accidents; witnessing each injury; bereavement; natural disasters; physical, sexual and emotional impose on; domestic violence and being a sufferer of crime) a child is exposed to is associated by elevated concentrations of the major emphasis hormone, cortisol.
There is also ground of belief that childhood maltreatment is associated with reduced brain volume and that these changes may have existence linked to anxiety.
What we raise
Looking at rats, we examined whether the impression of early life stress on the brain was exacerbated ~ the agency of drinking high volumes of sugary drinks hind weaning. As females are more likely to experience adverse life events, we carefully read female Sprague-Dawley rats.
To pattern early life trauma or abuse, in the pattern of rats were born half of the litters were exposed to limited nesting important from days two to nine after birth. They then returned to legitimate bedding until they were weaned. The limited nesting alters motherly behaviour and increases anxiety in the progeny later in life.
Sugar could have existence more damaging to the brain than trauma. from www.shutterstock.com
At weaning, moiety the rats were given unlimited to way of approach to low-fat chow and sprinkle and calender to drink, while their sisters were given chow, take in ~ and a 25% sugar solution that they could fix upon to drink. Animals exposed to in season life stress were smaller at weaning, only this difference disappeared over time. Rats consuming compliment in both groups (control and stress) ate more calories over the experiment.
The rats were followed until they were 15 weeks intelligent, and then their brains were examined. As we apprehend that early life stress can drive firmly together mental health and function, we examined a ingredient of the brain called the hippocampus, that is important for both memory and significance. Four groups of rats were studied – control (no stress), control rats tippling sugar, rats exposed to stress, and rats exposed to significance who drank sugar.
We found that deep-seated consumption of sugar in rats who were not stressed produced homogeneous changes in the hippocampus as seen in the rats who were stressed yet not drinking sugar. Early life inclemency exposure or sugar drinking led to diminish expression of the receptor that binds the major stress hormone cortisol, which may crave the ability to recover from exposure to a stressful situation.
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Another gene that is influential for the growth of nerves, Neurod1, was in addition reduced by both sugar and stress. Other genes important for the progress of nerves were investigated, and fair drinking sugar from a young mature years was sufficient to reduce them.
The rats were exposed to dark sugar intakes during development, and the pack together of the sugar is worrying in the manner that it may affect brain development, even if further work is required to proof this.
In this study, combining sweeten intake and early life stress did not originate further changes in the hippocampus, excepting whether this remains the case immersing time is unclear.
What does this servile for us?
The changes in the brain induced ~ dint of. sugar are of great concern given the to multuous consumption of sugar-sweetened beverages, with particularly high consumption in children stricken in years nine to 16 years. If resembling processes are at play in humans to what was found in our rat study, reducing the gradual wasting of sugar across the community is weighty.
The fact that drinking sugar or exposure to early life stress reduced the assertion of genes critical for brain increase and growth is of great touch. While it is impossible to transact such studies in humans, the brain circuits controlling stress responses and feeding are conserved from one side of to the other species.
People who were exposed to seasonable life trauma have changes in the conformation of their hippocampus. In humans, those consuming the ~ numerous “western” diet had smaller hippocampal volumes, in row with data from animal models.
Taken side by side, these findings suggest future work should consider possible long-term effects of boastful sugar intake, particularly early in life, forward the brain and behaviour.
Jayanthi Maniam, Research Associate, UNSW Australia and Margaret Morris, Professor of Pharmacology, Head of Pharmacology, UNSW Australia
This branch was originally published on The Conversation. Read the type article.
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Article spring: http://www.independent.co.uk/life-mode of address/health-and-families/health-news/flatter-may-be-as-damaging-to-the-brain-because-extreme-abuse-a6876896.html
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