Title: ADME Biochemist – focusing on Metabolism
Location: United Kingdom-United Kingdom (County level)-Sharnbrook-Colworth Science Park
Job Number: 150008J6
Job Title:
ADME Biochemist – focusing on Metabolism
Salary:
Competitive
Benefits
: These include annual bonus scheme, private healthcare, pension scheme and agile/flexible working.
Location:
Colworth Science Park, Bedford, UK
Travel:
10%
Business Context and Main Purpose of the Job:
The role sits within Unilever’s Safety and Environmental Assurance Centre, which is responsible for carrying out safety assessments of all Unilever products.
The role will involve leading and conducting the experimental design, execution, interpretation and reporting of in vitro biotransformation data to project teams in support of Unilever’s alternatives to animal testing programme.
You will provide leadership in the area of bioanalysis related to the ADME of chemicals as well as general biochemical expertise to inform risk assessment.
Specifically you will work closely in a project team exploring the application of modeling to provide advanced exposure assessments for consumers using Unilever products.
You will be required to work with a range of scientific experts in a number of different disciplines, including toxicologists, ecotoxicologists, computational chemists, microbiologists and occupational safety experts to translate analytical output into biological context.
Main Accountabilities:
Using an understanding of metabolic assays, their limitations and applicability, interpret metabolic pathways and identify metabolites
Develop innovative and novel approaches in bioanalysis/biotransformation to support exposure measurement, kinetic and mechanistic understanding of toxicity
Provide biochemistry input to help build and validate predictive models related to toxicology
Use sample preparation (e.g. SPE, SPME, partitioning techniques), chromatography (LC, GC) and hyphenated mass spectrometry techniques in the development and validation of methods for analysis of test substances, metabolites, contaminants, breakdown products, etc. in test matrices, biological samples and in-vitro/in-vivo/ex-vivo systems
Communicate with both experts and non-experts and publish scientific work internally and externally
Influence the internal scientific research strategy
Ensure scientific quality of experimental work and comply with the internal quality system in our GLP accredited facility.
Essential Skills, Experience and Qualifications:
Demonstrable practical experience in biotransformation assays and experimental metabolite identification techniques
Experience of using computational systems to predict metabolites and kinetics
Experience of bioanalytical LC-MS/MS method development and troubleshooting for quantitative analysis of compounds in diverse biological or complex matrices
Experience of trace level bioanalytical sample preparation techniques
Experience of metabolism modeling with knowledge of PBPK is desirable
GLP Study Director experience is desirable
PhD in relevant field or relevant BSc or equivalent with equivalent experience
Strong problem solving capability
Excellent written and verbal communication skills including the ability to convey complex scientific subject matter in a simple manner
Experience of working in multidisciplinary teams on research problems, contributing to scientific strategy.
REQUIRED LEADERSHIP BEHAVIOURS
•
Accountability & Responsibility
•
Growth Mindset
•
Bias for Action
COMPANY OVERVIEW
“I’m bringing haircare innovations to market faster – helping millions of consumers to look and feel great. I love being involved in a category that’s this exciting all the time.” Neesha, Senior Scientist.
Unilever is the global company behind powerhouse brands such as Flora, Dove, Persil and PG Tips. We have the huge ambition of doubling in size and improving billions of lives through of Sustainable Living Plan. And big ideas like our innovative new TRESemmé Split Remedy products are driving future growth. But to achieve our targets, we need more outstanding people like Neesha. With over 35 brands in the UK covering foods, home, personal care and refreshments, the sheer size and scope of roles in Research & Development are huge. All offer rewarding opportunities to work on great categories – solving real challenges, making a lasting impact, and creating better futures.
HOW TO APPLY
Hear more stories from our Unilever Makers and understand how you can start your own Unilever career at:
http://www.unilever.co.uk/careers-jobs/professionals/.
Or to apply now, click on “Apply to this job”. All candidate applications are reviewed in accordance with the criteria outlined for the job role. Please note that the closing date for the receipt of applications is 2nd June 2015.
Candidates who have applied online can track their application through the candidate tracking link or, if you have any additional queries, you may contact the Recruitment hotline number on 0800 0284390.
Job: Research/Development