In this article, I examine the prescient political/theoretical contributions of the Zapatista movement in the context of the emergence and decline of Latin America’s "progressive governments." Mexico’s ongoing and devastating social decomposition, and the structural crisis of contemporary capitalism. In doing so, I place the Zapatistas’ theorizations on the nature of "neoliberal globalization" in extended conversation with the work of Ernesto Laclau and Antonio Negri—both of whom have served as key referents for Latin America’s left. I argue that Zapatismo deserves to be taken seriously as an endeavor that both parallels and exceeds these more well-known theorists and thus allows for rather unique insights into what the recuperation of an anti-capitalist political horizon might require today.