England have already made history under coach Eddie Jones after extending their winning streak to 17 matches, but Scotland travel to Twickenham, London, on Saturday threatening to derail their 2017 Six Nations title bid.
The Red Rose have gone about the defence of their crown without much disruption thus far, but a surging Scottish side are looking to finish well under departing coach Vern Cotter in this weekend's Calcutta Cup clash.
The Scots are third in the standings and can mathematically climb to the table's summit providing Wales defeat Ireland in their clash at the Principality Stadium on Friday evening.
Scotland's record of two wins and one loss means they remain in the title pursuit for now, but the meeting in London on Saturday will decide whether or not that challenge is ready to live on into the tournament's final weekend.
Read on for a preview of Saturday's fixture, complete with a look at all the essential viewing information and the top headlines leading into the match.
Date: Saturday, March 11
Time: 4 p.m. GMT/11 a.m. ET
Venue: Twickenham, London
Live Stream: ITV Hub (UK)
TV Info: ITV (UK)
Cotter's Golden Opportunity
With Glasgow Warriors coach Gregor Townsend poised to take over as Scotland coach this summer, incumbent Cotter has a superb opportunity to bow out of his tenure on a high note in 2017.
Few might have expected the Scots would come into Week 4 of the competition with a chance to complete a Triple Crown should they defeat hosts England, but after wins over Wales and Ireland, that's the prize facing Cotter's men.
England may be unbeaten in their last 17 outings, but Scotland resource coach Nathan Hines recently admitted he's hoping that run will end up as more of a hindrance than a help, per BBC Sport:
When I was at Clermont, we went 77 games unbeaten at home, and that is a burden.
The pressure of, 'am I going to be part of the team that loses the record?' can be paralysing. I don't think we've got any expectation on us - we haven't won down there since 1983 and we're just going to focus on what we can do to win the game.
We'll prepare the best we can, but going on about 1983 is not going to do us any favours.
That's the kind of stubborn, no-holds-barred approach that saw Scotland take it to Ireland in this tournament's opening match before downing Wales 29-13 at Murrayfield in their most recent outing.
A dangerous set piece standing atop an unshakeable scrum in front of a back line showing tremendous hunger to score means Scotland have nothing to lose and absolutely everything to gain this Saturday.
Brutish Billy Back For England
Undoubtedly the most encouraging news emerging from the England camp this week was that Billy Vunipola should be fit to feature after impressing in his outing for Saracens last weekend.
The No. 8 has been out for some time with a knee injury, but there was speculation earlier in the week he might return to the starting line-up after the Telegraph revealed a slip-up from England:
In the end, however, Vunipola was named on the bench, with Nathan Hughes retaining his place in the side.
Wasps monolith Hughes has deputised at No. 8 in Vunipola's absence, but there's no denying the team has an altogether more obvious threat with their Saracens star at the base of the scrum.
Should Vunipola feature, the most Scotland can do is hope the fit-again brute is suffering from his time away from the pitch, lest he turn the fixture in favour of the home outfit.